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Fluctuations in fitness distributions and the effects of weak linked selection on sequence evolution.
MedLine Citation:
PMID:  23337315     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Evolutionary dynamics and patterns of molecular evolution are strongly influenced by selection on linked regions of the genome, but our quantitative understanding of these effects remains incomplete. Recent work has focused on predicting the distribution of fitness within an evolving population, and this forms the basis for several methods that leverage the fitness distribution to predict the patterns of genetic diversity when selection is strong. However, in weakly selected populations random fluctuations due to genetic drift are more severe, and neither the distribution of fitness nor the sequence diversity within the population are well understood. Here, we briefly review the motivations behind the fitness-distribution picture, and summarize the general approaches that have been used to analyze this distribution in the strong-selection regime. We then extend these approaches to the case of weak selection, by outlining a perturbative treatment of selection at a large number of linked sites. This allows us to quantify the stochastic behavior of the fitness distribution and yields exact analytical predictions for the sequence diversity and substitution rate in the limit that selection is weak.
Authors:
Benjamin H Good; Michael M Desai
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-18
Journal Detail:
Title:  Theoretical population biology     Volume:  -     ISSN:  1096-0325     ISO Abbreviation:  Theor Popul Biol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0256422     Medline TA:  Theor Popul Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier Inc.
Affiliation:
Department of Organismic and Evolutionary Biology, Department of Physics, and FAS Center for Systems Biology, Harvard University, United States.
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