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Fluctuations in coagulation activity among patients with atrial fibrillation who are stably anticoagulated.
MedLine Citation:
PMID:  19804076     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Atrial fibrillation is an important independent risk factor for stroke and increases the risk of systemic embolism. The individual risk depends on several clinical, environmental and biological factors. Additionally, a hypercoagulable state with abnormalities of hemostasia, thrombosis and platelet function have been observed in atrial fibrillation. This arrhythmia is also influenced by a disrupted circadian rhythm of hypercoagulable status implicated in the genesis of cardiovascular and cerebral diseases. The beneficial effect of oral anticoagulation therapy in atrial fibrillation has been confirmed by several studies. However, circadian variations in the degree of anticoagulation in these patients have also been described. In this review, the authors analyze the factors that might condition diurnal variations in thrombogenesis, hypercoagulability, and the extent of anticoagulation in patients with atrial fibrillation.
Authors:
Rocio González-Conejero; Francisco Marín; Javier Corral; Vanessa Roldán
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Future cardiology     Volume:  2     ISSN:  1744-8298     ISO Abbreviation:  Future Cardiol     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2009-10-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101239345     Medline TA:  Future Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  197-203     Citation Subset:  -    
Affiliation:
Centro de Hemodonación, Ronda de Garay s/n, 30003, Murcia, Spain. rocio.gonzalez@carm.es.
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