Document Detail

Fluconazole-resistant Kodamaea ohmeri fungemia associated with cellulitis: case report and review of the literature.
MedLine Citation:
PMID:  19411182     Owner:  NLM     Status:  MEDLINE    
Kodamaea (Pichia) ohmeri was formerly considered a contaminant, but is now known to be a significant human pathogen that has been shown to cause fungemia, endocarditis, funguria, and peritonitis in immunocompromised patients. We report a case of fungemia caused by K. ohmeri in a 71-year-old man with cellulitis. The patient was sent to the emergency room due to leg edema, fever, and change of consciousness. During hospitalization, a series of examinations including blood cultures were performed. On hospital day 8, blood culture yielded a yeast colony. Fluconazole was given empirically, but had no effect. The pathogen was identified as K. ohmeri by Vitek YBC card, API 20C, sequencing of the 18S rRNA gene, and the D1/D2 domains of the 26S rRNA gene and the internally transcribed spacer (ITS) regions. Antifungal susceptibility testing was performed with the ATB-Fungus system, and a high minimum inhibitory concentration (level up to 64 mg/l) for fluconazole was found. Fluconazole was replaced with amphotericin B deoxylate, and the fever and cellulitis inflammation gradually subsided. The patient was discharged in a stable condition. This is the first case of K. ohmeri fungemia in Taiwan.
Bing-Heng Yang; Ming-Yieh Peng; Shu-Jin Hou; Jun-Ren Sun; Shih-Yi Lee; Jang-Jih Lu
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-05-02
Journal Detail:
Title:  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases     Volume:  13     ISSN:  1878-3511     ISO Abbreviation:  Int. J. Infect. Dis.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-02     Completed Date:  2010-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610933     Medline TA:  Int J Infect Dis     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  e493-7     Citation Subset:  IM    
Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan.
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MeSH Terms
Antifungal Agents / pharmacology*
Cellulitis / complications,  microbiology*
Drug Resistance, Fungal*
Fluconazole / pharmacology*
Fungemia / microbiology*
Mycoses / complications,  microbiology
Pichia / classification,  drug effects*,  isolation & purification
Reg. No./Substance:
0/Antifungal Agents; 86386-73-4/Fluconazole

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