Document Detail


Fluconazole release from hydrogels including acrylamide-acrylic acid-itaconic acid, and their microbiological interactions.
MedLine Citation:
PMID:  18237492     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polyacrylamide (PAAm), polyacrylic acid (PAA), poly(acrylamide-co-itaconic acid) (PAAmIA) and poly(acrylic acid-co-itaconic acid) (PAAIA) hydrogels were prepared via free-radical polymerization using ethylene glycol dimethacrylate (EGDMA) as cross-linker. The variations of swelling percentages with time and pH were determined for these hydrogels at 37 degrees C. PAAmIA was found as the most swollen hydrogel at pH 4.0. SEM micrographs were taken to observe the morphology of the hydrogels. The less swollen hydrogel, PAAIA, displays less porosity relative to PAAmIA hydrogel. Fluconazole was entrapped into PAAmIA and PAAIA hydrogels and the release was investigated in Britton-Robinson buffer solution (BR) at pH 4.0 and 37 degrees C. The kinetic release parameters of the hydrogels, n and k, were calculated and Fickian-type diffusion was established for PAAmIA, which releases Fluconazole faster than PAAIA hydrogel. Therapeutic range was reached in the first hour for both hydrogels. Microbiological interactions of hydrogels were also studied in vitro in vaginal medium. It is found that Fluconazole entrapped in hydrogels inhibited the growth of Candida albicans.
Authors:
Mehlika Pulat; Haslet Eksi; Ufuk Abbasoglu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomaterials science. Polymer edition     Volume:  19     ISSN:  0920-5063     ISO Abbreviation:  J Biomater Sci Polym Ed     Publication Date:  2008  
Date Detail:
Created Date:  2008-02-01     Completed Date:  2008-05-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007393     Medline TA:  J Biomater Sci Polym Ed     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  193-205     Citation Subset:  IM    
Affiliation:
Gazi Universitesi Fen, Edebiyat Fakültesi, Kimya Bölümü, Teknikokullar, Ankara, Turkey. mpulat@gazi.edu.tr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acrylamide / chemistry
Acrylates / chemistry
Acrylic Resins / chemistry*
Antifungal Agents / chemistry,  pharmacology
Candida albicans / drug effects*
Drug Carriers*
Fluconazole / chemistry*,  pharmacology*
Hydrogels / chemical synthesis,  chemistry*
Hydrogen-Ion Concentration
Indicators and Reagents
Kinetics
Succinates / chemistry*
Chemical
Reg. No./Substance:
0/Acrylates; 0/Acrylic Resins; 0/Antifungal Agents; 0/Drug Carriers; 0/Hydrogels; 0/Indicators and Reagents; 0/Succinates; 79-06-1/Acrylamide; 79-10-7/acrylic acid; 86386-73-4/Fluconazole; 9003-01-4/carbopol 940; 97-65-4/itaconic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Shape memory in un-cross-linked biodegradable polymers.
Next Document:  Poly(lactic acid) scaffold fabricated by gelatin particle leaching has good biocompatibility for cho...