| Fluconazole pharmacokinetics and safety in premature infants. | |
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MedLine Citation:
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PMID: 22876898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Invasive candidiasis (IC) in the premature infant population is a common infection that results in substantial morbidity and mortality. For these patients, fluconazole is among the first line therapies to treat and prevent IC, and yet few prospective studies investigating its pharmacokinetics (PK) and safety have been performed in this vulnerable population. We review five phase I studies examining the PK of fluconazole in premature infants, which demonstrate markedly differing kinetics compared to adults. Based on these data, a treatment dose of 12 mg/kg/day, with the potential need of a loading dose of 25 mg/kg to achieve rapid steady state concentrations, achieves surrogate pharmacodynamic targets. Additionally, fluconazole appears to be safe to use in this population, with only minimal reversible hepatobiliary effects. |
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Authors:
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K Turner; P Manzoni; D K Benjamin; M Cohen-Wolkowiez; P B Smith; M M Laughon |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current medicinal chemistry Volume: 19 ISSN: 1875-533X ISO Abbreviation: Curr. Med. Chem. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-10-24 Completed Date: 2013-03-21 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9440157 Medline TA: Curr Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 4617-20 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antifungal Agents
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pharmacokinetics,
therapeutic use Candidiasis, Invasive / drug therapy Clinical Trials as Topic Fluconazole / pharmacokinetics*, therapeutic use Half-Life Humans Infant, Newborn Infant, Premature |
| Grant Support | |
ID/Acronym/Agency:
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HHSN267200700051C/HD/NICHD NIH HHS; K23 HD060040/HD/NICHD NIH HHS; K24 HD058735/HD/NICHD NIH HHS; R01 FD003519/FD/FDA HHS; R01 HD057956/HD/NICHD NIH HHS; T32 GM086330/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 86386-73-4/Fluconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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