| Fluconazole-induced congenital anomalies in three infants. | |
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MedLine Citation:
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PMID: 8838193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fluconazole has been associated with various teratisms in animals, including craniofacial ossification defects, thin, wavy ribs, and renal pelvis defects. We describe three infants born to women who were receiving fluconazole through or beyond the first trimester of pregnancy. All of the infants had congenital anomalies; no other drug was implicated. Only one of the three infants survived. Their anomalies, similar to those observed in animal studies, were largely craniofacial, skeletal (i.e., thin, wavy ribs and ossification defects), and cardiac. One of these infants was previously reported as having Antley-Bixler syndrome; however, given the chronology described herein and the similarity of this infant to the others, we conclude that her deformities also represent the potent teratogenic effect of fluconazole. |
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Authors:
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T J Pursley; I K Blomquist; J Abraham; H F Andersen; J A Bartley |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 22 ISSN: 1058-4838 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 1996 Feb |
Date Detail:
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Created Date: 1996-12-03 Completed Date: 1996-12-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 336-40 Citation Subset: IM |
Affiliation:
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Department of Medicine, Loma Linda University School of Medicine, California 92354, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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etiology* Adult Antifungal Agents / adverse effects* Bone and Bones / abnormalities Coccidioidomycosis / drug therapy Face / abnormalities Female Fluconazole / adverse effects* Heart Defects, Congenital / chemically induced Humans Infant, Newborn Male Meningitis, Fungal / drug therapy Pregnancy Pregnancy Complications, Infectious / drug therapy* Pregnancy Trimester, First Skull / abnormalities |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 86386-73-4/Fluconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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