| Fluconazole in the treatment of persistent coccidioidomycosis. | |
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MedLine Citation:
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PMID: 2306969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fluconazole is one of the new antifungal triazoles undergoing clinical trials. We used fluconazole at a dose of 50 or 100 mg/day in an open trial for the treatment of patients with persistent coccidioidomycosis. Fourteen patients were enrolled and treated for a mean of 13 +/- 7 months. Two failed to respond. Of the 12 who responded, one reactivated while being treated, and one died of myocardial infarction after successful treatment of his fungal infection; six had relapses from nine days to 15 months after treatment was stopped. Only four patients are asymptomatic at a mean of 14 +/- 3 months after cessation of treatment. Fluconazole is well tolerated at this dose. In view of its low toxicity, the partial clinical efficacy observed, and the high recurrence rate of chronic coccidioidal infection, it would be justified to try higher doses. |
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Authors:
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A Catanzaro; J Fierer; P J Friedman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chest Volume: 97 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1990 Mar |
Date Detail:
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Created Date: 1990-04-02 Completed Date: 1990-04-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 666-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Pulmonary and Critical Care Medicine, University of California, San Diego Medical Center. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Coccidioides Coccidioidomycosis / drug therapy*, pathology, radiography Dermatomycoses / drug therapy, pathology Female Fluconazole / administration & dosage, therapeutic use* Humans Lung Diseases, Fungal / drug therapy*, pathology, radiography Male Middle Aged Recurrence Time Factors |
| Chemical | |
Reg. No./Substance:
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86386-73-4/Fluconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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