Document Detail


Fluconazole in the treatment of persistent coccidioidomycosis.
MedLine Citation:
PMID:  2306969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fluconazole is one of the new antifungal triazoles undergoing clinical trials. We used fluconazole at a dose of 50 or 100 mg/day in an open trial for the treatment of patients with persistent coccidioidomycosis. Fourteen patients were enrolled and treated for a mean of 13 +/- 7 months. Two failed to respond. Of the 12 who responded, one reactivated while being treated, and one died of myocardial infarction after successful treatment of his fungal infection; six had relapses from nine days to 15 months after treatment was stopped. Only four patients are asymptomatic at a mean of 14 +/- 3 months after cessation of treatment. Fluconazole is well tolerated at this dose. In view of its low toxicity, the partial clinical efficacy observed, and the high recurrence rate of chronic coccidioidal infection, it would be justified to try higher doses.
Authors:
A Catanzaro; J Fierer; P J Friedman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  97     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-04-02     Completed Date:  1990-04-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  666-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Pulmonary and Critical Care Medicine, University of California, San Diego Medical Center.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Coccidioides
Coccidioidomycosis / drug therapy*,  pathology,  radiography
Dermatomycoses / drug therapy,  pathology
Female
Fluconazole / administration & dosage,  therapeutic use*
Humans
Lung Diseases, Fungal / drug therapy*,  pathology,  radiography
Male
Middle Aged
Recurrence
Time Factors
Chemical
Reg. No./Substance:
86386-73-4/Fluconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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