Document Detail

Flow transport and gas mixing during invasive high frequency oscillatory ventilation.
MedLine Citation:
PMID:  24656889     Owner:  NLM     Status:  Publisher    
A large Eddy simulation (LES) based computational fluid dynamics study was performed to investigate gas transport and mixing in patient specific human lung models during high frequency oscillatory ventilation. Different pressure-controlled waveforms (sinusoidal, exponential and square) and ventilator frequencies (15, 10 and 6Hz) were used (tidal volume=50mL). The waveforms were created by solving the equation of motion subjected to constant lung wall compliance and flow resistance. Simulations were conducted with and without endotracheal tube to understand the effect of invasive management device. Variation of pressure-controlled waveform and frequency exhibits significant differences on counter flow pattern, which could lead to a significant impact on the gas mixing efficiency. Pendelluft-like flow was present for the sinusoidal waveform at all frequencies but occurred only at early inspiration for the square waveform at highest frequency. The square waveform was most efficient for gas mixing, resulting in the least wall shear stress on the lung epithelium layer thereby reducing the risk of barotrauma to both airways and the alveoli for patients undergoing therapy.
Mohammed Alzahrany; Arindam Banerjee; Gary Salzman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-18
Journal Detail:
Title:  Medical engineering & physics     Volume:  -     ISSN:  1873-4030     ISO Abbreviation:  Med Eng Phys     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422753     Medline TA:  Med Eng Phys     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 IPEM. Published by Elsevier Ltd. All rights reserved.
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