Document Detail


Flow territory mapping of the cerebral arteries with regional perfusion MRI.
MedLine Citation:
PMID:  14988567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Conventional contrast-enhanced angiography is the gold standard for visualization of the vascular tree supplied by the major cerebral arteries and assessment of collateral flow. Thus far, however, no methods are available to assess the actual flow territories of the individual cerebral arteries. In the present study, we evaluate a noninvasive arterial spin labeling MRI method for selective mapping of the flow territories of the left and right internal carotid arteries and posterior circulation (basilar artery and vertebral arteries). METHODS: A spatially selective labeling approach, regional perfusion imaging, was developed on the basis of selective slab inversion of the arterial water with a pulsed arterial spin labeling sequence. The selectivity of this method was demonstrated. RESULTS: Regional perfusion imaging enables assessment of the perfusion territories of the major cerebral arteries. With selective labeling of an internal carotid artery, signal is present in both the ipsilateral anterior cerebral artery and ipsilateral middle cerebral artery flow territory. With labeling of the basilar artery, perfusion-weighted signal is symmetrically present in both posterior cerebral artery flow territories. Cerebral blood flow values measured with regional perfusion imaging in the complete hemisphere (40.1 mL x min(-1) x 100 g(-1) tissue), white matter (22.1 mL x min(-1) x 100 g(-1) tissue), and gray matter (65.8 mL x min(-1) x 100 g(-1) tissue) are in agreement with data in the literature. CONCLUSIONS: We present the first imaging method capable of evaluating both quantitatively and qualitatively the flow territories of the individual brain-feeding arteries in vivo.
Authors:
Jeroen Hendrikse; Jeroen van der Grond; Hanzhang Lu; Peter C M van Zijl; Xavier Golay
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2004-02-26
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  35     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-26     Completed Date:  2004-04-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  882-7     Citation Subset:  IM    
Affiliation:
Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands. j.hendrikse@azu.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Cerebral Arteries / anatomy & histology*
Cerebrovascular Circulation
Collateral Circulation
Female
Humans
Magnetic Resonance Angiography / methods*
Male
Middle Aged
Grant Support
ID/Acronym/Agency:
P41-RR15241/RR/NCRR NIH HHS; R01-NS31490/NS/NINDS NIH HHS; R21-EB000991/EB/NIBIB NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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