Document Detail


Flow-sensitive four-dimensional cine magnetic resonance imaging for offline blood flow quantification in multiple vessels: a validation study.
MedLine Citation:
PMID:  20815066     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To further validate the quantitative use of flow-sensitive four-dimensional velocity encoded cine magnetic resonance imaging (4D VEC MRI) for simultaneously acquired venous and arterial blood flow in healthy volunteers and for abnormal flow in patients with congenital heart disease.
MATERIALS AND METHODS: Stroke volumes (SV) obtained in arterial and venous thoracic vessels were compared between standard two-dimensional (2D), 4D VEC MRI with and without respiratory navigator gating (gated/nongated) in volunteers (n = 7). In addition, SV and regurgitation fractions (RF) measured in aorta or pulmonary trunk of patients with malformed and/or insufficient valves (n = 10) were compared between 2D and nongated 4D VEC MRI methods.
RESULTS: In volunteers and patients, Bland-Altman tests showed excellent agreement between 2D, gated, and nongated 4D VEC MRI obtained quantitative blood flow measurements. The bias between 2D and gated 4D VEC MRI was <0.5 mL for SV; between 2D and nongated 4D VEC MRI the bias was <0.7 mL for SV and <1% for RF.
CONCLUSION: Blood flow can be quantified accurately in arterial, venous, and pathological flow conditions using 4D VEC MRI. Nongated 4D VEC MRI has the potential to be suited for clinical use in patients with congenital heart disease who require flow acquisitions in multiple vessels.
Authors:
Sarah Nordmeyer; Eugénie Riesenkampff; Gérard Crelier; Alireza Khasheei; Bernhard Schnackenburg; Felix Berger; Titus Kuehne
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  32     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-03     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  677-83     Citation Subset:  IM    
Affiliation:
Deutsches Herzzentrum Berlin, Unit of Cardiovascular Imaging, Department of Congenital Heart Disease and Paediatric Cardiology, Berlin, Germany. snordmeyer@dhzb.de
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Analysis of Variance
Blood Flow Velocity
Case-Control Studies
Coronary Circulation / physiology
Female
Heart Defects, Congenital / diagnosis*
Humans
Image Enhancement / methods*
Magnetic Resonance Imaging, Cine / methods*
Male
Pulmonary Artery / physiology
Pulmonary Veins / physiology
Reference Values
Statistics, Nonparametric
Stroke Volume*
Vena Cava, Superior / physiology
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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