Document Detail

Flow recirculation zone length and shear rate are differentially affected by stenosis severity in human coronary arteries.
MedLine Citation:
PMID:  23241317     Owner:  NLM     Status:  Publisher    
Flow recirculation zones and shear strain are associated with distinct pathogenic biological pathways relevant to thrombosis and atherogenesis. The interaction between stenosis severity and lesion eccentricity in determining the length of flow recirculation zones and peak shear strain in human coronary arteries in vivo is unclear. Computational fluid dynamics (CFD) simulations were performed under resting and hyperemic conditions on computer-generated models and the three-dimensional reconstructions (3DRs) of coronary arteriograms of 25 patients. Boundary conditions for 3DR simulations were obtained by direct measurements using a pressure-temperature sensor guidewire. In the computer-generated models, stenosis severity and lesion eccentricity were strongly associated with recirculation zone length and maximum shear strain. In the 3DRs, eccentricity increased recirculation zone length and shear strain when comparing lesions of the same stenosis severity. However, across the whole population of coronary lesions, eccentricity did not correlate with recirculation zone length or shear strain (P= ns for both), whereas stenosis severity correlated strongly with both parameters (r=0.97, P<0.001 and r=0.96, P<0.001 respectively). Non-linear regression analyses demonstrated that the relationship between stenosis severity and peak shear was exponential, whereas the relationship between stenosis severity and recirculation zone length was sigmoidal, with an apparent threshold effect, demonstrating a steep increase in recirculation zone length between 40% and 60% area stenosis. Increasing stenosis severity and lesion eccentricity can both increase flow recirculation and shear strain in human coronary arteries. Flow recirculation is much more sensitive to mild changes in the severity of intermediate stenoses than is peak shear.
Ashkan Javadzadegan; Andy S C Yong; Michael Chang; Austin C C Ng; John Yiannikas; Martin K C Ng; Masud Behnia; Leonard Kritharides
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-15
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  -     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1The University of Sydney.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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