Document Detail


Flow rate and flow equation of pharmaceutical free-flowable powder excipients.
MedLine Citation:
PMID:  22149908     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Basic aspect of powder handling is powder flow which depends on mechanical properties of the solid material. This experimental work presents the results of flowability testing of the free-flowable particle size fraction of 0.0250-0.0315 cm of five powder excipients. The single-point determination of the mass flow rate from a cylindrical, flat-bottomed hopper was primarily influenced by the diameter of a circular orifice. The significant effect of the orifice height was also noted. Increasing the orifice height, the flow under gravity is directed resulting in the sudden acceleration of the flow rate. The critical zone relates to the orifice diameter. The multi-point determination of flowability employed the actual parameters of the flow equation which allows the prediction of the mass flow rate. The precision of the prediction was the basic criterion in optimization of the orifice geometry. Based on the results, the orifice height of 1.6 cm can be recommended for the correction of faster powder flow. For the slower powder flow, an orifice height of 0.2 cm can be used alternatively. In conclusion, the information about the orifice height used should be referred to whenever test the powder flowability and compare the results.
Authors:
Zdenka Sklubalová; Zdenek Zatloukal
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-10
Journal Detail:
Title:  Pharmaceutical development and technology     Volume:  -     ISSN:  1097-9867     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610932     Medline TA:  Pharm Dev Technol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy , Hradec Králové , Czech Republic.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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