Document Detail


Flow microfluorometric analysis of the cell cycle phase cytotoxicity of ARA-C.
MedLine Citation:
PMID:  7444164     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mouse L1210 leukemia cells killed by ara-C, an anti-tumor agent widely used against leukemia, were demonstrated to be in the S phase of the cell cycle by flow microfluorometry. The point in S phase at which the L1210 cells died was shown to be dose dependent. At higher concentrations of ara-C cells died earlier in the S phase.
Authors:
R A Hromas; D E Markel; V E Scholes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  30     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-02-26     Completed Date:  1981-02-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  365-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle / drug effects*
Cell Survival / drug effects
Cytarabine / pharmacology*
DNA, Neoplasm / metabolism
Fluorometry / methods
Leukemia L1210 / metabolism
Mice
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 147-94-4/Cytarabine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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