| Flow-mediated vasodilatation: variation and interrelationships with plasma lipids and lipoproteins. | |
| | |
MedLine Citation:
|
PMID: 18937098 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Endothelial dysfunction is a critical, prerequisite step in atherosclerosis, and may be evaluated by flow-mediated vasodilatation (FMD). The objective of this study was to examine interrelationships between FMD and plasma lipids and lipoproteins, and to determine the between-operator and within-subject variability associated with this technique. MATERIAL AND METHODS: FMD, plasma lipids and lipoproteins, including small dense LDL (sdLDL), were measured twice in 40 healthy volunteers, 4 weeks apart. Interrelationships between mean FMD responses and plasma lipids and lipoproteins were examined by correlation analysis. FMD measurements were taken by two independent operators, allowing determination of between-operator variability. Within-subject variability was determined by obtaining two measurements, 4 weeks apart, in every subject, and carried out by the same operator. RESULTS: FMD was inversely related to plasma triglycerides (r = -0.47, p = 0.002), total cholesterol/HDL cholesterol (r = -0.35, p = 0.03) and apolipoprotein B (r = -0.36, p = 0.02), but not to other plasma lipids and lipoproteins. When measuring variation in FMD, the following results were found: Between operators (SD = 4.0 FMD%) and within subjects (SD = 2.9 FMD%). CONCLUSIONS: The associations between FMD, plasma triglycerides and apoB provide evidence supporting a role for triglyceride-rich lipoproteins in endothelial dysfunction. |
| | |
Authors:
|
Jeppe Grøndahl Rasmussen; Rikke Bülow Eschen; Inge Valbak Aardestrup; Claus Dethlefsen; Bruce A Griffin; Erik Berg Schmidt |
Related Documents
:
|
9733228 - Accelerated cholesteryl ester transfer in patients with essential hypertension and the ... 1675948 - Circulating lipoprotein cholesterol concentrations in the summer-active ground squirrel... 9240248 - Changes in atherogenic lipids and lipoproteins during natural and hyperstimulated cycle... 2931988 - A randomized crossover comparison of two low-dose contraceptives: effects on serum lipi... 16159598 - Development of atherosclerosis in the diabetic balb/c mice. prevention with vitamin e a... 5459658 - An electron microscopic and functional study of very low density lipoproteins in intest... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Scandinavian journal of clinical and laboratory investigation Volume: 69 ISSN: 1502-7686 ISO Abbreviation: Scand. J. Clin. Lab. Invest. Publication Date: 2009 |
Date Detail:
|
Created Date: 2009-02-09 Completed Date: 2009-03-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0404375 Medline TA: Scand J Clin Lab Invest Country: Norway |
Other Details:
|
Languages: eng Pagination: 156-60 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Center for Cardiovascular Research Aalborg Hospital, Arhus University Hospitals, Denmark. jgr1@dadlnet.dk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Arteries / physiology Confidence Intervals Female Humans Lipoproteins / blood* Male Middle Aged Regional Blood Flow / physiology* Triglycerides / blood Vasodilation / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Lipoproteins; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: CGDB: a database of membrane protein/lipid interactions by coarse-grained molecular dynamics simulat...
Next Document: Angiotensin II type 1 receptor antagonists prevent glucose-induced increases in islet blood flow in ...