Document Detail

Flow-mediated dilatation and intima-media thickness in patients with lacunar infarctions.
MedLine Citation:
PMID:  16542168     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate systemic endothelial function and atherosclerotic changes in patients with lacunar infarctions (LI) we examined flow-mediated dilatation (FMD) and intima-media thickness (IMT) and compared them to patients with similar risk factors (SR) and healthy controls. METHODS: FMD and IMT were investigated in patients with LI (20 patients, aged 60.9 +/- 7.3 years), 21 age- and gender-matched patients with SR and 21 healthy controls. RESULTS: FMD was more impaired in patients with LI (0.4% +/- 5.0%) compared to patients with SR (3.8% +/- 4.8%) and healthy controls (7.9% +/- 6.0%) (P < or = 0.01), whereas IMT was similarly thickened in both groups of patients. CONCLUSIONS: We found that patients with LI have a diminished FMD, but a similar IMT, compared to patients with SR. Our results reveal that for a given level of atherosclerosis patients with LI have additional endothelial impairment.
J Pretnar-Oblak; M Sabovic; T Pogacnik; M Sebestjen; M Zaletel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  113     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-17     Completed Date:  2006-05-18     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  273-7     Citation Subset:  IM    
Department of Neurology, Ljubljana Medical Centre, Ljubljana, Slovenia.
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MeSH Terms
Brachial Artery / physiology
Brain Infarction / pathology*,  physiopathology*,  ultrasonography
Carotid Arteries / pathology,  ultrasonography
Case-Control Studies
Middle Aged
Regional Blood Flow / physiology
Tunica Intima / pathology*,  physiopathology,  ultrasonography
Tunica Media / pathology*,  physiopathology,  ultrasonography
Vasodilation / physiology*
Erratum In:
Acta Neurol Scand. 2006 May;113(5):357

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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