Document Detail

Flow-mediated dilatation is impaired by a high-saturated fat diet but not by a high-carbohydrate diet.
MedLine Citation:
PMID:  15774905     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: It is unknown whether a low-fat diet, which may elevate triglycerides and lower high-density lipoprotein (HDL) cholesterol, harms the endothelium. Our aim was to determine whether a low-fat, high-carbohydrate (CARB) diet impaired endothelial vasodilation compared with high saturated fat (SFA), monounsaturated fat (MUFA), or polyunsaturated fat (PUFA) diets. METHODS AND RESULTS: Forty healthy subjects were randomly crossed over to 4, 3-week isocaloric diets high in PUFA, MUFA, or SFA, containing at least 25 g of the relevant fat or a low-fat, CARB, high-glycemic load diet. Flow-mediated dilatation (FMD), fasting blood lipids, high sensitivity C-reactive protein, plasma intercellular, and vascular adhesion molecules plasma E- and P-selectin were measured after each intervention. SFA impaired FMD compared with all other diets (5.41+/-2.45% versus 10.80+/-3.69%; P=0.01). FMD did not change on CARB relative to MUFA or PUFA, despite 23% to 39% rises in triglyceride and 10% to 15% falls in HDL cholesterol. P-selectin was highest after SFA (121+/-52.7 ng/mL) versus MUFA (98+/-44.5 ng/mL; P=0.001) and PUFA (96+/-36.4 ng/mL; P=0.001). CONCLUSIONS: High SFA caused deterioration in FMD compared with high PUFA, MUFA, or CARB diets. Inflammatory responses may also be increased on this diet.
Jennifer B Keogh; Jessica A Grieger; Manny Noakes; Peter M Clifton
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2005-03-17
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  25     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-30     Completed Date:  2005-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1274-9     Citation Subset:  IM    
CSIRO Health Sciences and Nutrition, Adelaide BC, South Australia.
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MeSH Terms
Apolipoproteins B / blood
Atherosclerosis / diet therapy*,  immunology,  physiopathology*
Biological Markers
Blood Flow Velocity
Body Weight
Brachial Artery / physiology
Cross-Over Studies
Dietary Carbohydrates / administration & dosage*
Dietary Fats / administration & dosage*
Fatty Acids / administration & dosage*
Fatty Acids, Monounsaturated / administration & dosage
Fatty Acids, Unsaturated / administration & dosage
Insulin / blood
Middle Aged
Nutrition Assessment
Patient Compliance
Pulsatile Flow
Triglycerides / blood
Reg. No./Substance:
0/Apolipoproteins B; 0/Biological Markers; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Monounsaturated; 0/Fatty Acids, Unsaturated; 0/Triglycerides; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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