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Flow-mediated K(+) secretion in horses intoxicated with lolitrem B (perennial ryegrass staggers).
MedLine Citation:
PMID:  23134178     Owner:  NLM     Status:  Publisher    
Abstract AIM: To investigate the effects of lolitrem B intoxication on renal K(+) secretion in response to increased tubular flow rates. METHODS: Results are derived from a repeated measure pilot study of seven horses fed non-perennial ryegrass feed for a week prior to exposing them to perennial ryegrass seed and hay that contained an average of 2 ppm lolitrem B. At the end of the control and treatment period frusemide (1 mg/kg I/V) was administered and serial fractional excretion of K(+)(FEK(+)) and fractional excretion of Na(+)(FENa(+)) calculated. Baseline concentration of aldosterone in plasma, serum K(+)concentration and feed K(+) concentration were also compared. RESULTS: Key findings included a reduced change in FEK(+) from 0 to 15 minutes in response to frusemide administration (p=0.022, Wilcoxon signed-rank test) and a reduced baseline concentration of aldosterone in plasma (p=0.022, Wilcoxon signed-rank test) during the treatment period compared with the control. CONCLUSIONS: Results suggest that lolitrem B intoxication reduced flow-mediated K(+) secretion and interfered with aldosterone production or secretion. However, further investigation is required to validate these findings and to further elucidate the underlying pathophysiology. CLINICAL RELEVANCE: Lolitrem B intoxication in horses may cause disruption to electrolyte handling in addition to neurological deficits.
Lk Johnstone; Ig Mayhew
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-8
Journal Detail:
Title:  New Zealand veterinary journal     Volume:  -     ISSN:  0048-0169     ISO Abbreviation:  N Z Vet J     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0021406     Medline TA:  N Z Vet J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a New Bolton Centre, University of Pennsylvania , 382 West Street Road, Kennett Square , Pennsylvania , 19384 , United States.
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