| Flow loaded canine carotid artery. II. Ultrastructural changes in the subendothelial layer. | |
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MedLine Citation:
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PMID: 3604678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To study the subendothelial layer of the flow loaded arteries, blood flow changes were produced by constructing an arterio-venous shunt between the common carotid artery and the external jugular vein using eleven adult beagle dogs. One week after operation, the subendothelial layer of the flow loaded canine carotid arteries was observed with a transmission electron microscope. In the arteries loaded by highly elevated blood flow, the subendothelial layer showed thick subendothelial space (300 to 500 nm) with multilayered basement membrane. The microfilaments and microfibrils increased significantly. There were no collagen fibers. Spindle to cylindrical elastic fibers appeared in the luminal margin of the internal elastic lamina. On the other hand, in the control arteries, the subendothelial layer was thin (about 50 nm) with scanty basement-membrane-like material. There were a few microfilaments and microfibrils, but no collagen fibers. The luminal margin of the internal elastic lamina was smooth. It is suggested that these are the wall shear stress dependent subendothelial changes, which would be partly due to the increased protein synthesis by the endothelial cells stimulated by the wall shear stress and be partly due to the wall shear dependent mechanical stress transmitted from the endothelial surface. |
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Authors:
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H Masuda; N Saito; K Kawamura; T Shozawa; A Kanazawa; M Sageshima |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta pathologica japonica Volume: 37 ISSN: 0001-6632 ISO Abbreviation: Acta Pathol. Jpn. Publication Date: 1987 Feb |
Date Detail:
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Created Date: 1987-08-05 Completed Date: 1987-08-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372637 Medline TA: Acta Pathol Jpn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 239-51 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteriovenous Shunt, Surgical Basement Membrane / ultrastructure Blood Flow Velocity Carotid Arteries / physiology, ultrastructure* Dogs Endothelium / ultrastructure Female Microscopy, Electron Morphogenesis |
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