| Flow interactions with cells and tissues: cardiovascular flows and fluid-structure interactions. Sixth International Bio-Fluid Mechanics Symposium and Workshop, March 28-30, 2008, Pasadena, California. | |
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MedLine Citation:
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PMID: 20336826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interactions between flow and biological cells and tissues are intrinsic to the circulatory, respiratory, digestive and genitourinary systems. In the circulatory system, an understanding of the complex interaction between the arterial wall (a living multi-component organ with anisotropic, nonlinear material properties) and blood (a shear-thinning fluid with 45% by volume consisting of red blood cells, platelets, and white blood cells) is vital to our understanding of the physiology of the human circulation and the etiology and development of arterial diseases, and to the design and development of prosthetic implants and tissue-engineered substitutes. Similarly, an understanding of the complex dynamics of flow past native human heart valves and the effect of that flow on the valvular tissue is necessary to elucidate the etiology of valvular diseases and in the design and development of valve replacements. In this paper we address the influence of biomechanical factors on the arterial circulation. The first part presents our current understanding of the impact of blood flow on the arterial wall at the cellular level and the relationship between flow-induced stresses and the etiology of atherosclerosis. The second part describes recent advances in the application of fluid-structure interaction analysis to arterial flows and the dynamics of heart valves. |
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Authors:
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Morton H Friedman; Rob Krams; Krishnan B Chandran |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of biomedical engineering Volume: 38 ISSN: 1521-6047 ISO Abbreviation: Ann Biomed Eng Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-24 Completed Date: 2010-06-30 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 1178-87 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / physiopathology* Atherosclerosis / physiopathology* Blood Cells / physiology* Blood Flow Velocity / physiology Humans Mechanotransduction, Cellular / physiology* Models, Cardiovascular* |
| Grant Support | |
ID/Acronym/Agency:
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R56 HL071814-05A1/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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