| Flow input waveform effects on the temporal and spatial wall shear stress gradients in a femoral graft-artery connector. | |
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MedLine Citation:
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PMID: 8950654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Employing a validated finite volume code, a computer-aided design of the distal end of a femoral graft-artery junction has been considered to simulate transient three-dimensional blood flow for various flow input waveforms. The study relies on the hypothesis that large sustained wall shear stress gradients play a major role in the rapid recurrence of intimal hyperplasia plus atheroma after bypass surgery, leading to early graft failure. Two new dimensionless parameters have been introduced to correlate flow waveform characteristics with the severity of nonuniform hemodynamics and hence the potential risk for restenosis. The transient and, more importantly, the time-averaged wall shear stress gradient distributions shown, map out the junction areas which are still susceptible to restenosis, especially the toe region. Future geometric modifications will further reduce disturbed flow patterns and hence the probability of graft failure. |
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Authors:
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C Kleinstreuer; M Lei; J P Archie |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomechanical engineering Volume: 118 ISSN: 0148-0731 ISO Abbreviation: J Biomech Eng Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-02-25 Completed Date: 1997-02-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7909584 Medline TA: J Biomech Eng Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 506-10 Citation Subset: IM |
Affiliation:
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Department of Mechanical & Aerospace Engineering, North Carolina State University, Raleigh, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anastomosis, Surgical Arteries / physiopathology, surgery* Computer Simulation* Computer-Aided Design Femoral Artery / physiopathology, transplantation* Hemodynamics / physiology Humans Models, Cardiovascular* Stress, Mechanical Surface Properties |
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