Document Detail

Flow-injection chemiluminescent determination of cefprozil using Tris (2,2'-bipyridyl) ruthenium (II)-permanganate system.
MedLine Citation:
PMID:  16682164     Owner:  NLM     Status:  MEDLINE    
A rapid and sensitive chemiluminescence (CL) method using flow-injection (FI) has been developed for the determination of a second generation cephalosporin, cefprozil. The method is based on the CL reaction of cefprozil with acidic potassium permanganate and tris (2,2'-bipyridyl) ruthenium (II), Ru (bipy)3(2+). The CL intensity is greatly enhanced when quinine sulfate is used as a sensitizer. After optimization of the different experimental parameters, a calibration graph was obtained over a concentration range of 0.1-3.0 microg ml(-1) with minimum detectability of 0.005 microgml(-1) (S/N=3). The correlation coefficient was 0.9998 (n=6) with a relative standard deviation (%R.S.D.) of 1.63% for 2.0 microgml(-1). The proposed method was successfully applied to commercial tablets. The average percentage recovery (n=6) was 99.9+/-1.40.
Nawal A Alarfaj; Sawsan A Abd El-Razeq
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Publication Detail:
Type:  Journal Article     Date:  2006-05-06
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  41     ISSN:  0731-7085     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-30     Completed Date:  2006-08-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  England    
Other Details:
Languages:  eng     Pagination:  1423-7     Citation Subset:  IM    
Medical Studies and Sciences Sections, Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia.
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MeSH Terms
Cephalosporins / analysis*
Chemiluminescent Measurements / methods*
Chromatography, High Pressure Liquid
Flow Injection Analysis / methods
Potassium Permanganate
Reg. No./Substance:
0/Cephalosporins; 7722-64-7/Potassium Permanganate; 92665-29-7/cefprozil

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