| Flow-injection chemiluminescent determination of cefprozil using Tris (2,2'-bipyridyl) ruthenium (II)-permanganate system. | |
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MedLine Citation:
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PMID: 16682164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A rapid and sensitive chemiluminescence (CL) method using flow-injection (FI) has been developed for the determination of a second generation cephalosporin, cefprozil. The method is based on the CL reaction of cefprozil with acidic potassium permanganate and tris (2,2'-bipyridyl) ruthenium (II), Ru (bipy)3(2+). The CL intensity is greatly enhanced when quinine sulfate is used as a sensitizer. After optimization of the different experimental parameters, a calibration graph was obtained over a concentration range of 0.1-3.0 microg ml(-1) with minimum detectability of 0.005 microgml(-1) (S/N=3). The correlation coefficient was 0.9998 (n=6) with a relative standard deviation (%R.S.D.) of 1.63% for 2.0 microgml(-1). The proposed method was successfully applied to commercial tablets. The average percentage recovery (n=6) was 99.9+/-1.40. |
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Authors:
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Nawal A Alarfaj; Sawsan A Abd El-Razeq |
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Publication Detail:
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Type: Journal Article Date: 2006-05-06 |
Journal Detail:
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Title: Journal of pharmaceutical and biomedical analysis Volume: 41 ISSN: 0731-7085 ISO Abbreviation: J Pharm Biomed Anal Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-05-30 Completed Date: 2006-08-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309336 Medline TA: J Pharm Biomed Anal Country: England |
Other Details:
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Languages: eng Pagination: 1423-7 Citation Subset: IM |
Affiliation:
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Medical Studies and Sciences Sections, Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cephalosporins
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analysis* Chemiluminescent Measurements / methods* Chromatography, High Pressure Liquid Colorimetry Flow Injection Analysis / methods Potassium Permanganate |
| Chemical | |
Reg. No./Substance:
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0/Cephalosporins; 7722-64-7/Potassium Permanganate; 92665-29-7/cefprozil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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