| Flow injection-chemiluminescence determination of amoxycillin using potassium permanganate and formaldehyde system. | |
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MedLine Citation:
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PMID: 15685663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It was found that amoxycillin can react with potassium permanganate in an acidic medium to produce chemiluminescence, which is greatly enhanced by formaldehyde. The optimum conditions for this chemiluminescent reaction were studied in detail using a flow-injection system. The experimental results indicate that, under optimum conditions, the chemiluminescence intensity is linearly related to the concentration of amoxycillin in the range 5.48 x 10(-8)-2.74 x 10(-6) mol/L, with a detection limit (3sigma) of 4.1 x 10(-8) mol/L. The relative standard deviation was 1.0% at 1.1 x 10(-6) mol/L amoxycillin (n = 11 measurements). This method has the advantages of high sensitivity, fast response and ease of operation. The method was successfully applied to the determination of amoxycillin in raw medicines and capsules. |
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Authors:
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Wei Cao; Jing-He Yang; Chang-Xia Sun; Yan-Jing Chen; Qing-Fei Gao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Luminescence : the journal of biological and chemical luminescence Volume: 20 ISSN: 1522-7235 ISO Abbreviation: Luminescence Publication Date: 2005 Jan-Feb |
Date Detail:
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Created Date: 2005-02-07 Completed Date: 2005-06-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100889025 Medline TA: Luminescence Country: England |
Other Details:
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Languages: eng Pagination: 20-4 Citation Subset: IM |
Affiliation:
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School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amoxicillin
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analysis* Anti-Bacterial Agents / analysis* Chemiluminescent Measurements / methods* Drug Design Flow Injection Analysis / methods* Formaldehyde / chemistry* Hydrogen-Ion Concentration Kinetics Potassium Permanganate / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 26787-78-0/Amoxicillin; 50-00-0/Formaldehyde; 7722-64-7/Potassium Permanganate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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