Document Detail

Flow injection analysis of cholic acids in pharmaceutical preparations using a polymeric membrane ISE as detector.
MedLine Citation:
PMID:  10898158     Owner:  NLM     Status:  MEDLINE    
The results reported in this paper regard the setting up of a polymeric membrane ISE that is selective for cholic acids (CA) and able to work in a flow system, especially in flow injection analysis (FIA), based on the exchanger (tetrakisdecylammoniumcholate, TDACh), which has proved effective, is of very simple but suitable structure and is above all easy to synthesise starting from commercially available chemicals. A complete analytical characterisation of the sensor was performed working both in batch conditions and in FIA, using in the latter case a 'wall jet' type of flow cell. The response toward different bile acid sodium salts such as the CA, deoxycholic (DCA), chenodeoxycholic (CDCA), ursodeoxycholic (UDCA), taurocholic (TCA) sodium salts was checked. The application to the analysis of different commercial drugs by FIA was also performed to determine the UDCA or CDCA acid content of several pharmaceutical formulations. Lastly, a preliminary study is presented concerning the use of the investigated electrochemical sensor as high performance liquid chromatography (HPLC) detector.
O Arias De Fuentes; L Campanella; G Crescentini; A Falcioni; M P Sammartino; M Tomassetti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  23     ISSN:  0731-7085     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-10-16     Completed Date:  2000-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  89-98     Citation Subset:  IM    
Department of Chemistry, University of Rome La Sapienza, Rome, Italy.
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MeSH Terms
Cholic Acids / analysis*
Chromatography, High Pressure Liquid
Flow Injection Analysis
Membranes, Artificial*
Reproducibility of Results
Reg. No./Substance:
0/Cholic Acids; 0/Membranes, Artificial; 0/Polymers

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