Document Detail


Flow in the left anterior descending coronary artery in patients with migraine headache.
MedLine Citation:
PMID:  23972351     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Migraine is a common neurovascular disorder characterized by attacks of severe headache, autonomic and neurologic symptoms. Migraine can affect many systems in the body, yet its effects on cardiovascular system are unclear. We hypothesized that migraine and coronary microvascular angina may be manifestations of a common systemic microvascular dysfunction and clinically associated. Forty patients with migraine and 35 healthy volunteers were included into the study. Using transthoracic Doppler echocardiography, coronary flow was visualized in the middle or distal part of the left anterior descending artery. Coronary diastolic peak flow velocities were measured with pulse wave Doppler at baseline and after dipyridamole infusion (0.56 mg/kg/4 min). Coronary flow reserve of <2 was considered normal. In addition, thorough 2-dimensional and Doppler echocardiographic examinations were also performed. Fifty-two women and 23 men were included. Coronary flow reserve was significantly lesser in the migraine group than in the control group (1.99 ± 0.3 vs 2.90 ± 0.5, p <0.05). In addition, mitral annular velocities were lower and the ratio of early mitral inflow velocity to early mitral annular velocity (E/E' lateral and E/E' septal) was higher in migraineurs than in the control group (p <0.05 for all), indicating diastolic function abnormalities in the migraine group. In conclusion, these findings suggest that there is an association between coronary microvascular dysfunction and migraine independently of the metabolic state of the patients. A common pathophysiologic pathway of impaired endothelial vasodilatation, vasomotor dysfunction, and increased systemic inflammatory factors may play a role in these 2 clinical conditions and could be the underlying cause of subclinical systolic and diastolic left ventricular dysfunction in migraineurs.
Authors:
Gamze Aslan; Leyla Elif Sade; Begum Yetis; Huseyin Bozbas; Serpil Eroglu; Bahar Pirat; Ufuk Can; Haldun Muderrisoglu
Publication Detail:
Type:  Journal Article     Date:  2013-08-22
Journal Detail:
Title:  The American journal of cardiology     Volume:  112     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-04     Completed Date:  2014-01-07     Revised Date:  2014-02-27    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1540-4     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Blood Flow Velocity / physiology*
Coronary Circulation / physiology*
Coronary Vessels / physiopathology*,  ultrasonography
Echocardiography
Echocardiography, Doppler
Endothelium, Vascular / physiopathology
Female
Follow-Up Studies
Humans
Male
Microvascular Angina / etiology*,  physiopathology,  ultrasonography
Middle Aged
Migraine Disorders / etiology,  physiopathology*,  ultrasonography
Mitral Valve / physiopathology,  ultrasonography
Retrospective Studies
Vasodilation
Ventricular Dysfunction, Left / complications*,  physiopathology,  ultrasonography
Young Adult
Comments/Corrections
Comment In:
Am J Cardiol. 2014 Feb 1;113(3):570   [PMID:  24433605 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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