Document Detail


Flow-dependent pulmonary vasodilation during acute unilateral pulmonary artery occlusion in Jungle Fowl.
MedLine Citation:
PMID:  9565247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Giant Jungle Fowl previously were shown to be highly resistant to the onset of pulmonary hypertension syndrome (PHS, ascites) under conditions that induce a substantial incidence of PHS in broiler chickens. In the present study, lightly anesthetized, clinically healthy 12- to 13-wk-old male Giant Jungle Fowl maintained a lower respiratory rate, a similar hematocrit, and superior arterial blood gas values when compared with 6-wk-old male broilers. Giant Jungle Fowl weighed less than broilers (1,860 +/- 19 vs 2,788 +/- 63 g, respectively) and had equivalent absolute values for pulmonary arterial pressure, cardiac output, and pulmonary vascular resistance. Acute unilateral pulmonary artery occlusion in Giant Jungle Fowl doubled the pulmonary vascular resistance and forced the right ventricle to propel a sustained 60% increase in blood flow through the vasculature of the unoccluded lung. A transient increase in pulmonary arterial pressure initially was required to overcome the vascular resistance of the unoccluded lung; however, flow-dependent vasodilation gradually reduced the pulmonary vascular resistance and permitted pulmonary arterial pressure to return toward control levels. Unilateral pulmonary artery occlusion also triggered an immediate reduction in the partial pressure of oxygen in arterial blood, and the gradual return of pulmonary arterial pressure toward control levels did not eliminate this ventilation-perfusion mismatch, which has been attributed to blood flowing too rapidly through the unoccluded lung to permit diffusive gas equilibration. The inherent capacity for flow-dependent pulmonary vasodilation may reduce the susceptibility of Giant Jungle Fowl to PHS by reducing the increment in pulmonary arterial pressure required to propel an elevated blood flow through the lungs.
Authors:
R F Wideman; M F Forman; J D Hughes; Y K Kirby; N Marson; N B Anthony
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Poultry science     Volume:  77     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-06-18     Completed Date:  1998-06-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  615-26     Citation Subset:  IM    
Affiliation:
Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA. rwideman@comp.uark.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Birds / physiology*
Blood Gas Analysis / veterinary
Blood Pressure / physiology
Body Weight / physiology
Carbon Dioxide / blood
Cardiac Output / physiology
Catheterization / veterinary
Chickens / physiology*
Cohort Studies
Heart Rate / physiology
Hydrogen-Ion Concentration
Linear Models
Male
Oxygen / blood
Oxygen Consumption / physiology
Pulmonary Artery / physiology*,  surgery
Regional Blood Flow
Vascular Resistance
Vasodilation / physiology*
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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