Document Detail


Flow-dependent antiarrhythmic properties of ammonia during catecholamine-driven ventricular tachycardia.
MedLine Citation:
PMID:  1581859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fifteen mongrel dogs weighing 22-34 kg were instrumented to investigate the antiarrhythmic effects of ammonia (0.1-0.2 mmol/min ammonium hydroxide), adenosine (1.87 mumol/min), and saline (0.9% NaCl) during norepinephrine-driven ventricular tachycardia, under conditions of controlled and natural coronary blood flow. Under natural flow conditions, the severe ectopy caused by norepinephrine (100-800 ng.kg-1.min-1) was reduced by 42 +/- 4% after 30 s of ammonia infusion. Adenosine infusion reduced percent ectopy by 97 +/- 2% at 30 s. Ammonia also significantly increased coronary blood flow by 26 +/- 4%, while adenosine increased blood flow by 72 +/- 14%. Saline infusion had no significant effect on either the severity of ventricular tachycardia or coronary blood flow. Norepinephrine consistently caused coronary functional hyperemia as previously reported. When coronary blood flow was controlled by a peristaltic pump to match natural coronary blood flow and to prevent norepinephrine-induced coronary functional hyperemia, the antiarrhythmic effects of ammonia were lost while those of adenosine were unaffected. Additionally, increasing coronary blood flow manually during norepinephrine-induced ventricular tachycardia, to a level seen with combined norepinephrine and ammonia under natural flow conditions, appeared to worsen the ventricular arrhythmias. We conclude that the antiarrhythmic properties of ammonia against norepinephrine-driven ventricular tachycardia might be dependent on coronary blood flow, while those of adenosine are independent of coronary blood flow.
Authors:
A Malootian; G S Friedrichs; G F Merrill
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  70     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-06-16     Completed Date:  1992-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  94-9     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Rutgers University, New Brunswick, NJ.
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MeSH Terms
Descriptor/Qualifier:
Adenosine / pharmacology
Ammonia / pharmacology*
Animals
Anti-Arrhythmia Agents / pharmacology*
Coronary Circulation / physiology
Dogs
Female
Male
Norepinephrine
Tachycardia / chemically induced,  drug therapy*,  physiopathology
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 51-41-2/Norepinephrine; 58-61-7/Adenosine; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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