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Flow cytometric pattern recognition of lymph node biopsies with lymphomas that lack lineage characteristics.
MedLine Citation:
PMID:  24750671     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Although immunophenotyping (IPT) using flow cytometry is a routine technique that is applied in many laboratories as a diagnostic tool for lymphadenopathy, some diagnostic challenges persist. In this review, we will discuss pitfalls in the daily practice of lymph node diagnostics with the focus on general characteristics as lymphoid scatter patterns and lineage specific antigens that are used to define lymphoid populations. The absence of these characteristics on proliferating lymphoid cells can potentially lead to a wrong diagnosis. At the same time, this provides evidence for malignant transformation. Sporadic examples of reactive lymphoid proliferations with similar phenotypes are also discussed, illustrating the need for correlating IPT with morphology and clinical features.
Authors:
K Hebeda; F Preijers
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of laboratory hematology     Volume:  36     ISSN:  1751-553X     ISO Abbreviation:  Int J Lab Hematol     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-04-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101300213     Medline TA:  Int J Lab Hematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  254-60     Citation Subset:  IM    
Copyright Information:
© 2014 John Wiley & Sons Ltd.
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