Document Detail


Flow cytometric analysis of tumor antigen TA-4 in cervical cytologic specimens.
MedLine Citation:
PMID:  2418939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Flow cytometric analysis of cellular contents of TA-4, a tumor antigen of squamous cell carcinoma, was performed in vaginal smears from 143 women. Abnormal findings, characterized by a cell peak with high fluorescence intensity, appeared in 85.7% of cases (54/63) of cervical squamous cell carcinoma, 80% of cases (4/5) of severe dysplasia, 42.9% of cases (3/7) of mild-to-moderate dysplasia, and in 20.6% of cases of healthy women (13/63). Cellular compositions sorted from abnormal cell fractions with high fluorescence intensity consisted, not only of malignant cells but also of morphologically nonmalignant cells. Immunohistochemical studies indicated that these nonmalignant cells with high TA-4 content originated from the intermediate layer of squamous epithelium adjacent to the cancer nest. These findings indicate that this method may be a useful approach for investigating some biologic characteristics of cells and for detecting cervical cancer or its precursors.
Authors:
Y Suehiro; H Kato; M Nagai; T Torigoe
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer     Volume:  57     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-04-07     Completed Date:  1986-04-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1380-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Antigens, Neoplasm / analysis*
Carcinoma, Squamous Cell / immunology,  pathology*
Cell Separation
Epithelium / immunology
Female
Flow Cytometry
Humans
Immunoenzyme Techniques
Neoplasm Staging
Staining and Labeling
Uterine Cervical Neoplasms / immunology,  pathology*
Vaginal Smears
Chemical
Reg. No./Substance:
0/Antigens, Neoplasm; 0/tumor antigen TA-4, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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