| Flow cytometric S-phase fraction contributes to diagnosis of diploid malignant salivary gland tumours. | |
| | |
MedLine Citation:
|
PMID: 16829041 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
DNA ploidy studies on salivary gland tumours have shown that the proportion of aneuploid cases, although confined to the malignant entities, is considerably lower than for other solid malignancies. To analyse whether the S-phase fraction (SPF) may contribute to discrimination of diploid malignant from benign tumours, DNA flow cytometric data from 45 different malignant salivary gland tumours was compared with that of 121 pleomorphic adenomas. All benign tumours were diploid. Twelve malignant tumours contained aneuploid cell populations. The SPF values for diploid malignancies ranged between 0.9% and 11.0% (mean 3.9%), and between 0.5% and 7.9% (mean 2.7%) for pleomorphic adenomas. A 4% cut-off value gained statistical significance for discriminating diploid malignant tumours from pleomorphic adenomas (P<0.01). The sensitivity for SPF>4% was 46% and the positive predictive value was 40%. A sensitivity of 60% and a positive predictive value of 54% was achieved by combining aneuploidy and SPF>4%. These results show that DNA flow cytometry may contribute to diagnostic assessment in salivary gland tumours. |
| | |
Authors:
|
O Driemel; K Kraft; J Hemmer |
Publication Detail:
|
Type: Evaluation Studies; Journal Article Date: 2006-07-07 |
Journal Detail:
|
Title: International journal of oral and maxillofacial surgery Volume: 35 ISSN: 0901-5027 ISO Abbreviation: Int J Oral Maxillofac Surg Publication Date: 2006 Oct |
Date Detail:
|
Created Date: 2006-10-18 Completed Date: 2007-01-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8605826 Medline TA: Int J Oral Maxillofac Surg Country: Denmark |
Other Details:
|
Languages: eng Pagination: 947-50 Citation Subset: D; IM |
Affiliation:
|
Department of Oral and Maxillofacial Surgery, University of Regensburg, 89053 Regensburg, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenoma, Pleomorphic
/
diagnosis,
genetics,
pathology Adult Aged Aged, 80 and over Aneuploidy DNA, Neoplasm / analysis* Diagnosis, Differential Diploidy* Epidemiologic Methods Female Flow Cytometry / methods* Humans Male Middle Aged S Phase* / genetics Salivary Gland Neoplasms / diagnosis*, genetics, pathology Salivary Glands / pathology |
| Chemical | |
Reg. No./Substance:
|
0/DNA, Neoplasm |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oculo-facio-cardio-dental syndrome in a mother and daughter.
Next Document: Multiple independent spike foci and epilepsy, with special reference to a new epileptic syndrome of ...