| Flow analysis of ventricular assist device inflow and outflow cannula positioning using a naturally shaped ventricle and aortic branch. | |
| | |
MedLine Citation:
|
PMID: 20964698 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Tip geometry and placement of rotary blood pump inflow and outflow cannulae influence the dynamics of flow within the ventricle and aortic branch. Cannulation, therefore, directly influences the potential for thrombus formation and end-organ perfusion during ventricular assist device (VAD) support or cardiopulmonary bypass (CPB). The purpose of this study was to investigate the effect of various inflow/outflow cannula tip geometries and positions on ventricular and greater vessel flow patterns to evaluate ventricular washout and impact on cerebral perfusion. Transparent models of a dilated cardiomyopathic ventricle and an aortic branch were reconstructed from magnetic resonance imaging data to allow flow measurements using particle image velocimetry (PIV). The contractile function of the failing ventricle was reproduced pneumatically, and supported with a rotary pump. Flow patterns were visualized around VAD inflow cannulae, with various tip geometries placed in three positions in the ventricle. The outflow cannula was placed in the subclavian artery and at several positions in the aorta. Flow patterns were measured using PIV and used to validate an aortic flow computational fluid dynamic study. The PIV technique indicated that locating the inflow tip in the left ventricular outflow tract improved complete ventricular washout while the tip geometry had a smaller influence. However, side holes in the inflow cannula improved washout in all cases. The PIV results confirmed that the positioning and orientation of the outflow cannula in the aortic branch had a high impact on the flow pattern in the vessels, with a negative blood flow in the right carotid artery observed in some cases. Cannula placement within the ventricle had a high influence on chamber washout. The positioning of the outflow cannula directly influences the flow through the greater vessels, and may be responsible for the occasional reduction in cerebral perfusion seen in clinical CPB. |
| | |
Authors:
|
Marco Laumen; Tim Kaufmann; Daniel Timms; Peter Schlanstein; Sebastian Jansen; Shaun Gregory; Kai Chun Wong; Thomas Schmitz-Rode; Ulrich Steinseifer |
Related Documents
:
|
11831748 - Performance and scale-up of adsorptive membrane chromatography. 9212938 - Flow visualization studies to improve the spiral pump design. 2730808 - Experience in reducing the hemolysis of an impeller assist heart. 17122378 - A novel, fully implantable, multichannel biotelemetry system for measurement of blood f... 6742148 - Effect of polycythemia on vascular volume in the newborn dog. 9402098 - Blood flow limitations of solute transport across the visceral peritoneum. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Artificial organs Volume: 34 ISSN: 1525-1594 ISO Abbreviation: Artif Organs Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
|
Languages: eng Pagination: 798-806 Citation Subset: IM |
Copyright Information:
|
© 2010, Copyright the Authors. Artificial Organs © 2010, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc. |
Affiliation:
|
Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Aachen, Germany. laumen@hia.rwth-aachen.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cerebral cortical dynamics during visuomotor transformation: adaptation to a cognitive-motor executi...
Next Document: Interaction of an idealized cavopulmonary circulation with mechanical circulatory assist using an in...