Document Detail


Flow residence time and regions of intraluminal thrombus deposition in intracranial aneurysms.
MedLine Citation:
PMID:  20499185     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thrombus formation in intracranial aneurysms, while sometimes stabilizing lesion growth, can present additional risk of thrombo-embolism. The role of hemodynamics in the progression of aneurysmal disease can be elucidated by patient-specific computational modeling. In our previous work, patient-specific computational fluid dynamics (CFD) models were constructed from MRI data for three patients who had fusiform basilar aneurysms that were thrombus-free and then proceeded to develop intraluminal thrombus. In this study, we investigated the effect of increased flow residence time (RT) by modeling passive scalar advection in the same aneurysmal geometries. Non-Newtonian pulsatile flow simulations were carried out in base-line geometries and a new postprocessing technique, referred to as "virtual ink" and based on the passive scalar distribution maps, was used to visualize the flow and estimate the flow RT. The virtual ink technique clearly depicted regions of flow separation. The flow RT at different locations adjacent to aneurysmal walls was calculated as the time the virtual ink scalar remained above a threshold value. The RT values obtained in different areas were then correlated with the location of intra-aneurysmal thrombus observed at a follow-up MR study. For each patient, the wall shear stress (WSS) distribution was also obtained from CFD simulations and correlated with thrombus location. The correlation analysis determined a significant relationship between regions where CFD predicted either an increased RT or low WSS and the regions where thrombus deposition was observed to occur in vivo. A model including both low WSS and increased RT predicted thrombus-prone regions significantly better than the models with RT or WSS alone.
Authors:
V L Rayz; L Boussel; L Ge; J R Leach; A J Martin; M T Lawton; C McCulloch; D Saloner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-05-25
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  38     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-16     Completed Date:  2010-12-30     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3058-69     Citation Subset:  IM    
Affiliation:
Department of Radiology, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA. vlrayz@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Blood Flow Velocity
Humans
Imaging, Three-Dimensional*
Intracranial Aneurysm / pathology,  physiopathology*
Magnetic Resonance Angiography / methods
Models, Cardiovascular*
Thrombosis / pathology,  physiopathology*
Grant Support
ID/Acronym/Agency:
K25NS059891/NS/NINDS NIH HHS; R01NS059944/NS/NINDS NIH HHS
Comments/Corrections

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