| Flow-Mediated Vasodilation Measurements in Cavalier King Charles Spaniels with Increasing Severity of Myxomatous Mitral Valve Disease. | |
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MedLine Citation:
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PMID: 22151409 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Cardiovascular disease is associated with endothelial dysfunction in humans and studies of plasma biomarkers suggest that dogs with myxomatous mitral valve disease (MMVD) might also have endothelial dysfunction. HYPOTHESIS: That progression of mitral regurgitation (MR) is associated with development of endothelial dysfunction. ANIMALS: Forty-three Cavalier King Charles Spaniels (CKCS) with MR of varying severity. METHODS: Privately owned CKCS were prospectively recruited and divided in 4 groups: (1) 12 CKCS with minimal MR; (2) 9 CKCS with mild MR; (3) 11 CKCS with moderate-severe MR; and (4) 11 CKCS with moderate-severe MR and clinical signs compatible with heart failure. Dogs underwent blood sampling, echocardiography, blood pressure (BP) recordings, and flow-mediated vasodilation (FMD) measurements. The effect of progressive MR on FMD was determined by multivariate analyses. RESULTS: Flow-mediated vasodilation decreased with progression of MR. Group 4 (4.79 ± 3.22%) had significantly lower FMD than groups 1 (10.40 ± 4.58%) and 2 (10.14 ± 3.67%) (P < .005) and group 3 (6.79 ± 3.98%) had a significantly lower FMD than group 1 (P = .03). Increasing left ventricular end-diastolic diameter (P = .0004, R(2) = 0.27) and the combination of age (P = .01) and body weight (P = .002) (R(2) = 0.31) were significantly associated with reduced FMD. FMD did not correlate with sex, BP, or plasma markers. CONCLUSIONS AND CLINICAL IMPORTANCE: Reduced FMD indicates that increased disease severity in CKCS with MMVD is associated with development of endothelial dysfunction which might be a future therapeutic and/or diagnostic target. |
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Authors:
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S G Moesgaard; C Klostergaard; N E Zois; T Teerlink; M Molin; T Falk; C E Rasmussen; V Luis Fuentes; I D Jones; L H Olsen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-13 |
Journal Detail:
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Title: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine Volume: - ISSN: 1939-1676 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708660 Medline TA: J Vet Intern Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 by the American College of Veterinary Internal Medicine. |
Affiliation:
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Department of Basic Animal and Veterinary Sciences. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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