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Flow-Mediated Dilation Is Acutely Improved following High-Intensity Interval Exercise.
MedLine Citation:
PMID:  22648341     Owner:  NLM     Status:  Publisher    
PURPOSE: Cardiovascular disease is characterized by decreased endothelial function. Chronic exercise training improves endothelial function in individuals with cardiovascular diseases; however, the acute endothelial responses to a single bout of exercise are not consistent in the literature. This study investigated if a single bout of moderate-intensity endurance exercise (END) and low-volume high-intensity interval exercise (HIT) on a cycle ergometer resulted in similar acute changes in endothelial function. METHODS: Ten individuals (66 ± 11 yrs) with coronary artery disease participated in two exercise sessions (END and HIT). Endothelial-dependent function was assessed using brachial artery flow-mediated dilation (FMD) pre- and 60 minutes post-exercise. Brachial artery diameters and velocities were determined using Doppler ultrasound before and after a 5-minute ischemic period at all time points. Endothelial-independent function was assessed using a 0.4-mg sublingual dose of nitroglycerin. RESULTS: Total work performed was higher in END (166 ± 52 kJ) compared to HIT (93 ± 28 kJ) exercise (p<0.001). Endothelial-dependent function improved (p=0.01) following END (absolute FMD pre: 0.24 ± 0.18 mm; post: 0.31 ± 0.24 mm) and HIT (absolute FMD pre: 0.25 ± 0.13 mm; post: 0.29 ± 0.13 mm), with no differences between exercise conditions. A time effect for FMD normalized to the shear rate area under the curve was also observed (p=0.02) after END (pre: 0.005 ± 0.004, post: 0.010 ± 0.011) and HIT (pre: 0.005 ± 0.004, post: 0.009 ± 0.011). Endothelial-independent function responses were unchanged following END and HIT (p>0.05). CONCLUSIONS: HIT and END resulted in similar acute increases in brachial artery endothelial-dependent function in a population with dysfunction at rest, despite the difference in exercise intensities.
Katharine D Currie; Robert S McKelvie; Maureen J Macdonald
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-29
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Department of Kinesiology, McMaster University, Hamilton, ON, Canada 2Department of Medicine, McMaster University, Hamilton, ON, Canada 3Hamilton Health Sciences, Hamilton, ON, Canada.
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