| Flow assessment through four heart valves simultaneously using 3-dimensional 3-directional velocity-encoded magnetic resonance imaging with retrospective valve tracking in healthy volunteers and patients with valvular regurgitation. | |
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MedLine Citation:
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PMID: 19724233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To validate 3-dimensional (3D) 3-directional velocity-encoded (VE) magnetic resonance imaging (MRI) for flow assessment through all 4 heart valves simultaneously with retrospective valve-tracking during off-line analysis in healthy volunteers and in patients with valvular regurgitation. MATERIAL AND METHODS: Three-dimensional 3-directional VE MRI was performed in 22 healthy volunteers and in 29 patients with ischemic cardiomyopathy who were suspected of valvular regurgitation and net flow volumes through the 4 heart valves were compared. Furthermore, the analysis was repeated for each valve in 10 healthy volunteers and in 10 regurgitant valves to assess intra- and interobserver agreement for assessment of respectively net flow volumes and regurgitation fraction. RESULTS: In healthy volunteers, the average net flow volume through the mitral valve, tricuspid valve, aortic valve, and pulmonary valve was 85 +/- 20 mL, 85 +/- 21 mL, 83 +/- 19 mL, 82 +/- 21 mL, respectively. Strong correlations between net flow volumes through the 4 heart valves were observed (intraclass correlation coefficients [ICC] 0.93-0.95) and the coefficient of variance (CV) was small (6%-9%). The repeated analysis by the same observer and by a second observer yielded good agreement for measurement of net flow volumes (ICC: 0.93-0.99 and CV: 3%-7%). Strong correlations between the net flow volumes through the 4 heart valves were also observed in the patients with valvular regurgitation (ICC: 0.85-0.95 and CV: 7%-18%). The average net flow volume through the mitral valve, tricuspid valve, aortic valve, and pulmonary valve was 63 +/- 20 mL, 63 +/- 20 mL, 63 +/- 20 mL, 63 +/- 20 mL, respectively. Furthermore, the intra- and interobserver agreement for assessment of regurgitation fraction was good (ICC: 0.86 and 0.85, CV: 12% and 13%). CONCLUSIONS: Flow assessment using 3D 3-directional VE MR with retrospective valve-tracking during off-line analysis enables accurate quantification of net flow volumes through 4 heart valves within a single acquisition in healthy volunteers and in patients with valvular regurgitation. |
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Authors:
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Stijntje D Roes; Sebastiaan Hammer; Rob J van der Geest; Nina Ajmone Marsan; Jeroen J Bax; Hildo J Lamb; Johan H C Reiber; Albert de Roos; Jos J M Westenberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Investigative radiology Volume: 44 ISSN: 1536-0210 ISO Abbreviation: Invest Radiol Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2010-04-12 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 669-75 Citation Subset: IM |
Affiliation:
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Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aortic Valve Insufficiency / diagnosis, physiopathology* Blood Flow Velocity Female Humans Image Enhancement / methods Image Interpretation, Computer-Assisted / methods* Magnetic Resonance Imaging / methods* Male Middle Aged Mitral Valve Insufficiency / diagnosis, physiopathology* Pulmonary Valve Insufficiency / diagnosis, physiopathology* Reproducibility of Results Retrospective Studies Sensitivity and Specificity Tricuspid Valve Insufficiency / diagnosis, physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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