Document Detail


Flourine-18 flourodeoxyglucose positron emission tomography as a non-invasive test of disease activity in Takayasu's arteritis--a report of four cases.
MedLine Citation:
PMID:  20152937     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Takayasu's arteritis (TA) is a rare disease affecting the large arteries, particularly the aorta. Standard test to demonstrate abnormal vascular anatomy is angiography. This invasive procedure is limited in differentiating inflammatory and fibrotic lesions. Acute phase reactants have shown to have poor sensitivity and specificity in confirming disease activity in TA patients. Fluorine-18 flourodeoxyglucose Positron Emission Tomography (FDG-PET) scan has been utilized to detect areas of active inflammation in neoplastic, infectious and recently, vasculitic conditions.
OBJECTIVE: To describe the FDG-PET scan findings of patients with Takayasu's arteritis.
METHODS: This is a case series of four patients fulfilling the American College of Rheumatology classification criteria for TA. They were evaluated with FDG-PET scan to establish disease activity in correlation with other clinical and laboratory features.
RESULTS: Three out of four patients showed evidence of increased radiotracer uptake in the aorta. Of these three patients, one had increased radiotracer uptake in the lungs secondary to active pulmonary tuberculosis.
CONCLUSION: PET scan is a promising but non-specific tool that provides clinicians with a non-invasive measure of disease activity in TA patients. Further studies confirming its utility in monitoring disease activity and response to treatment is recommended.
Authors:
Evan Glenn S Vista; Paul V Santos Estrella; Juan Javier T Lichauco
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-02-10
Journal Detail:
Title:  Autoimmunity reviews     Volume:  9     ISSN:  1873-0183     ISO Abbreviation:  Autoimmun Rev     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-11     Completed Date:  2010-09-20     Revised Date:  2013-04-26    
Medline Journal Info:
Nlm Unique ID:  101128967     Medline TA:  Autoimmun Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  503-6     Citation Subset:  IM    
Copyright Information:
2010. Published by Elsevier B.V.
Affiliation:
St. Luke's Medical Center, Quezon City, Philippines. evanvistamd@omrf.ouhsc.org
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticoagulants / therapeutic use
Asthma / complications,  diagnosis*,  physiopathology,  therapy
Constriction, Pathologic
Diagnosis, Differential
Disease Progression
Female
Fluorodeoxyglucose F18 / metabolism
Humans
Immunosuppressive Agents / therapeutic use
Middle Aged
Positron-Emission Tomography*
Sensitivity and Specificity
Takayasu Arteritis / complications,  diagnosis*,  physiopathology,  therapy
Tuberculosis, Pulmonary / complications,  diagnosis*,  physiopathology,  therapy
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Immunosuppressive Agents; 63503-12-8/Fluorodeoxyglucose F18

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