| Florfenicol residues in Nile tilapia after 10-d oral dosing in feed: effect of fish size. | |
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MedLine Citation:
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PMID: 19485121 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nile tilapia Oreochromis niloticus were medicated with florfenicol (AQUAFLOR type A medicated article; Schering-Plough Animal Health, Summit, New Jersey) via a medicated ration at 15 mg florfenicol x kg fish body weight(-1) d(-1) for 10 d to compare the elimination kinetics of the test article in different size fish held at 25 degrees C. The groups of fish used in the study had mean weights of approximately 100, 250, and 500 g. In each trial, the fish were provided the medicated ration and 15 fish were processed at each of seven time points postfeeding for determination of the florfenicol concentration in serum and the florfenicol residue in the edible portion (composite muscle and skin). There was a trend toward shorter half-lives of elimination in the smaller fish. The elimination times in muscle-skin (times to reach the established tolerance concentration for channel catfish Ictalurus punctatus and salmonids of 1.0 microg florfenicol residue/g) and half-lives were 9.2 and 1.2 d (100 g), 8.6 and 1.7 d (250 g), and 12.7 and 2.2 d (500 g), respectively. |
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Authors:
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P R Bowser; R E Kosoff; C-Y Chen; G A Wooster; R G Getchell; J L Craig; P Lim; S E Wetzlich; A L Craigmill; L A Tell |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of aquatic animal health Volume: 21 ISSN: 0899-7659 ISO Abbreviation: J. Aquat. Anim. Health Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-06-02 Completed Date: 2009-07-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9884881 Medline TA: J Aquat Anim Health Country: United States |
Other Details:
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Languages: eng Pagination: 14-7 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA. prb4@cornell.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animal Feed Animals Anti-Bacterial Agents / metabolism* Body Weight / physiology* Cichlids / physiology* Drug Residues* Species Specificity Thiamphenicol / analogs & derivatives*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 15318-45-3/Thiamphenicol; 73231-34-2/florfenicol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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