| Floral variant of follicular lymphoma containing marginal zone B-cell component. Report of two cases. | |
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MedLine Citation:
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PMID: 16218941 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We here report two unusual cases of floral variant of follicular lymphoma containing marginal zone B-cells. Histologically, the neoplastic follicles consisted of three distinct layers. The inner layer was composed of neoplastic germinal centers exhibiting a floral design and the middle layer had unusually prominent mantle zones. The outer zone of neoplastic follicles was surrounded by a pale cuff of marginal zone B-cells. Immunohistological study demonstrated that both the germinal center and marginal zone component lay within the follicular dendritic cell network. The germinal center component was CD10+ and bcl-2+. However, a portion of the marginal zone component weakly expressed bcl-2 but not CD10. Nodal marginal zone B-cell lymphoma (NMZBL) occasionally possesses "floral" lymphoid follicles. Follicular lymphoma with marginal zone differentiation is a high-risk variant of follicular lymphoma. In diagnostic practice, the differential diagnosis between the floral variant of follicular lymphoma containing marginal zone B-cells and the "floral variant" of NMZBL is important. |
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Authors:
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M Kojima; H Tanaka; H Matsuda; M Iijima; T Motoori; N Masawa |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica Volume: 113 ISSN: 0903-4641 ISO Abbreviation: APMIS Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-10-12 Completed Date: 2006-01-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803400 Medline TA: APMIS Country: Denmark |
Other Details:
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Languages: eng Pagination: 638-42 Citation Subset: IM |
Affiliation:
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Department of Pathology and Clinical Laboratories, Gunma Cancer Center Hospital, Ohta, Japan. mkojima@gunma-cc.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult B-Lymphocytes / immunology* Female Humans Lymph Nodes / immunology, pathology* Lymphoma, Follicular / immunology, pathology* Male Middle Aged |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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