| FloSeal use in endoscopic sinus surgery: effect on postoperative bleeding and synechiae formation. | |
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MedLine Citation:
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PMID: 16500469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The objective of this study is to evaluate the effect of the hemostatic agent, FloSeal (FS), on bleeding and healing after functional endoscopic sinus surgery. METHODS: We performed randomized, double-blinded, controlled study at a tertiary care center. Patient nasal sides were randomized to FS or control. After completion of sinus surgery, FS was placed in the appropriate nasal cavities followed by saline-soaked neuropatties in both nasal cavities. Control sides received saline-soaked neuropatties alone, without FS. RESULTS: Forty-five patients were enrolled. Mean time to cessation of bleeding in recovery was 16.4 and 30.8 minutes for the FS- and control-treated sides, respectively (P = .028). Patients maintained diaries for 7 days postoperatively and reported similar durations of bleeding at home, but indicated less discomfort on the FS-treated side. Postoperative endoscopic examinations revealed significantly less crusting in FS-treated nasal cavities at 1 week, but significant difference at 1 and 3 months. There were no differences in postoperative scarring or middle turbinate lateralization. CONCLUSIONS: Use of FS after functional endoscopic sinus surgery resulted in less bleeding, immediately postoperatively, and less discomfort, and did not increase the incidence of crusting or scarring compared with control. |
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Authors:
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Mark Jameson; Charles W Gross; Stilianos E Kountakis |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of otolaryngology Volume: 27 ISSN: 0196-0709 ISO Abbreviation: Am J Otolaryngol Publication Date: 2006 Mar-Apr |
Date Detail:
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Created Date: 2006-02-27 Completed Date: 2006-08-10 Revised Date: 2007-07-24 |
Medline Journal Info:
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Nlm Unique ID: 8000029 Medline TA: Am J Otolaryngol Country: United States |
Other Details:
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Languages: eng Pagination: 86-90 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology-Head and Neck Surgery, University of Virginia Health System, Charlottesville, VA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Chi-Square Distribution Double-Blind Method Endoscopy* Female Gelatin Sponge, Absorbable / therapeutic use* Hemostatics / therapeutic use* Humans Male Middle Aged Paranasal Sinus Diseases / surgery* Postoperative Hemorrhage / prevention & control* Treatment Outcome Wound Healing / drug effects |
| Chemical | |
Reg. No./Substance:
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0/FloSeal Matrix; 0/Hemostatics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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