Document Detail

Flight activity, mortality rates, and lipoxidative damage in Drosophila.
MedLine Citation:
PMID:  16510857     Owner:  NLM     Status:  MEDLINE    
In this study, the effect of flight activity on mortality rates and lipoxidative damage in Drosophila was determined to identify mechanisms through which oxidative damage affects life span. The results showed that flies allowed flying throughout life had higher mortality rates and decreased median and maximum life spans compared to controls. The mortality rate of the flight activity group could be lowered, but not completely reversed by switching to control conditions; and the accrued oxidative damage could not be eliminated. The levels of reactive oxygen species produced by mitochondria isolated from high activity and control flies did not differ significantly. However, the high activity flies had altered membrane fatty acid compositions, which made them prone to increased lipid peroxidation. The effect of flight activity on insect life span differs considerably from the beneficial effects of exercise in mammals; these differences may be caused by physiological differences between the two taxa.
Tapiwanashe Magwere; Reinald Pamplona; Satomi Miwa; Pedro Martinez-Diaz; Manuel Portero-Otin; Martin D Brand; Linda Partridge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  61     ISSN:  1079-5006     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-03-02     Completed Date:  2006-04-24     Revised Date:  2014-10-14    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  136-45     Citation Subset:  AIM; IM    
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MeSH Terms
Drosophila melanogaster
Flight, Animal / physiology*
Lipid Peroxidation / physiology*
Longevity / physiology*
Mitochondrial Proteins / analysis
Grant Support
SF19106//Biotechnology and Biological Sciences Research Council; //Wellcome Trust
Reg. No./Substance:
0/Mitochondrial Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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