Document Detail


Flight activity, mortality rates, and lipoxidative damage in Drosophila.
MedLine Citation:
PMID:  16510857     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, the effect of flight activity on mortality rates and lipoxidative damage in Drosophila was determined to identify mechanisms through which oxidative damage affects life span. The results showed that flies allowed flying throughout life had higher mortality rates and decreased median and maximum life spans compared to controls. The mortality rate of the flight activity group could be lowered, but not completely reversed by switching to control conditions; and the accrued oxidative damage could not be eliminated. The levels of reactive oxygen species produced by mitochondria isolated from high activity and control flies did not differ significantly. However, the high activity flies had altered membrane fatty acid compositions, which made them prone to increased lipid peroxidation. The effect of flight activity on insect life span differs considerably from the beneficial effects of exercise in mammals; these differences may be caused by physiological differences between the two taxa.
Authors:
Tapiwanashe Magwere; Reinald Pamplona; Satomi Miwa; Pedro Martinez-Diaz; Manuel Portero-Otin; Martin D Brand; Linda Partridge
Related Documents :
15759697 - A scale value for the balance inside a historical opera house.
16452597 - Laryngeal ultrasound: a useful method in predicting post-extubation stridor. a pilot st...
23516057 - Exercise intensity of robot-assisted walking versus overground walking in nonambulatory...
9451537 - The "space cycle" self powered human centrifuge: a proposed countermeasure for prolonge...
21530357 - Paroxysmal exercise-induced dyskinesia with self-limiting partial epilepsy: a novel glu...
3805547 - The effects of albuterol on sulfur dioxide-induced bronchoconstriction in allergic adol...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  61     ISSN:  1079-5006     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-03-02     Completed Date:  2006-04-24     Revised Date:  2007-08-13    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  136-45     Citation Subset:  AIM; IM    
Affiliation:
Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Drosophila melanogaster
Flight, Animal / physiology*
Lipid Peroxidation / physiology*
Longevity / physiology*
Male
Mitochondrial Proteins / analysis
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Mitochondrial Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Impaired interleukin-12-dependent T-cell functions during aging: role of signal transducer and activ...
Next Document:  Water balance and cation levels in Drosophila: can early physiological decline predict aging and lon...