Document Detail


Flexible and micro-porous chitosan hydrogel/nano ZnO composite bandages for wound dressing: In vitro & in vivo evaluation.
MedLine Citation:
PMID:  22489770     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Current wound dressings have de-merits like less flexibility, poor mechanical strength, lack of porosity, tendency of dressings to adhere onto the wound surface and majority of the dressings did not possess antibacterial activity. Hydrogel based wound dressings would be helpful to provide cooling sensation, moisture environment and act as barrier to microbes. To overcome these hassles, we have developed flexible and micro-porous chitosan hydrogel/nano zinc oxide composite bandage (CZB) by the incorporation zinc oxide nanoparticles (nZnO) into chitosan hydrogel. The prepared nanocomposite bandages were characterized using FT-IR, XRD and SEM. In addition, swelling, degradation, blood clotting, antibacterial, cytocompatibility, cell attachment on the material and cell infiltration into the composite bandages were evaluated. The nanocomposite bandage showed enhanced swelling, blood clotting and antibacterial activity. Cytocompatibility of the composite bandage has been analyzed in normal human dermal fibroblast cells. Cell attachment and infiltration studies showed that the cells were found attached on to the nanocomposite bandages and penetrated into the interior. Further, the in vivo evaluations in sprague-dawley rats revealed that, these nanocomposite bandages enhanced the wound healing and helped for faster re-epithelialization and collagen deposition. The obtained data strongly encourage the use of these composite bandages for burn wound, chronic wound and diabetic foot ulcers.
Authors:
P T Sudheesh Kumar; Vinoth Kumar Lakshmanan; T V Anilkumar; C Ramya; P Reshmi; A G Unnikrishnan; Shantikumar V Nair; Jayakumar Rangasamy
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-11
Journal Detail:
Title:  ACS applied materials & interfaces     Volume:  -     ISSN:  1944-8252     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101504991     Medline TA:  ACS Appl Mater Interfaces     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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