Document Detail

Flecainide-induced JT prolongation, T wave inversion and ventricular tachycardia during treatment for symptomatic atrial fibrillation.
MedLine Citation:
PMID:  8077075     Owner:  NLM     Status:  MEDLINE    
Two hours after taking 100 mg of flecainide, a patient developed gastrointestinal complaints, dizziness and shortness of breath. The ECG demonstrated novel prolonged JT interval with negative T wave in the precordial leads. During admission, several attacks of non-sustained ventricular tachycardia occurred. The plasma drug concentration was 814 mg/l. Although the tachycardia was non-sustained, cardiovascular collapse developed. Serum electrolytes were normal and myocardial infarction was excluded. The patient is now free of symptoms without medications.
S A Said; S T Somer; H A Oude Luttikhuis
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  44     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-10-06     Completed Date:  1994-10-06     Revised Date:  2006-07-12    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  285-7     Citation Subset:  IM    
Department of Cardiology, Streekziekenhuis Midden-Twente, Hengelo, The Netherlands.
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MeSH Terms
Atrial Fibrillation / drug therapy,  therapy*
Electric Countershock
Flecainide / adverse effects*,  therapeutic use
Heart Conduction System / drug effects*
Tachycardia, Ventricular / chemically induced*
Reg. No./Substance:

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