Document Detail


Flecainide acetate in atrial flutter and fibrillation. The arrhythmogenic effects.
MedLine Citation:
PMID:  2107078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The arrhythmogenic effects of flecainide in atrial fibrillation and flutter were assessed in a consecutive material of 100 patients without severe heart failure (NYHA class I or II). Severe arrhythmogenic events occurred in 9% (4-16%) of the patients: within the first 5 days of treatment in seven patients, and in two patients after 60 and 240 days of flecainide treatment. Patients with proarrhythmic events tended to be older and to have a longer QRS duration. Following flecainide therapy conversion to sinus rhythm was achieved in 21 of 43 patients (49%) with atrial fibrillation and in 10 of 29 (34%) with atrial flutter. It is concluded that flecainide, although an effective antiarrhythmic drug, has potential proarrhythmic effects and therefore cautious use of this drug is mandatory.
Authors:
I Sihm; F A Hansen; J Rasmussen; A K Pedersen; K Thygesen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  11     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-04-24     Completed Date:  1990-04-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  145-8     Citation Subset:  IM    
Affiliation:
Department of Medicine and Cardiology, Aarhus County and University Hospital, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Arrhythmias, Cardiac / chemically induced*
Atrial Fibrillation / drug therapy*
Atrial Flutter / drug therapy*
Flecainide / adverse effects*,  therapeutic use
Humans
Middle Aged
Chemical
Reg. No./Substance:
54143-55-4/Flecainide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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