Document Detail

Flecainide and antiarrhythmic effects in a mouse model of catecholaminergic polymorphic ventricular tachycardia.
MedLine Citation:
PMID:  22867967     Owner:  NLM     Status:  MEDLINE    
Recent studies have shown that flecainide may be an effective therapy to prevent life-threatening arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. Several hypotheses have been advanced to explain the antiarrhythmic mechanism of flecainide, including Na(+) channel blockade and a direct inhibitory action on the ryanodine receptor. In this article, we review the current literature on the topic and summarize the elements of the existing debate.
Nian Liu; Carlo Napolitano; Luigi A Venetucci; Silvia G Priori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-08-04
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  22     ISSN:  1873-2615     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-09-12     Completed Date:  2013-02-19     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Anti-Arrhythmia Agents / pharmacokinetics,  therapeutic use*
Disease Models, Animal
Flecainide / pharmacokinetics,  therapeutic use*
Myocytes, Cardiac / drug effects*
Tachycardia, Ventricular / drug therapy*,  prevention & control
Grant Support
FS/10/63/28374//British Heart Foundation; GGP06007//Telethon
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Catecholamines; K94FTS1806/Flecainide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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