Document Detail


Flavonol-cinnamate cycloadducts and diamide derivatives from Aglaia laxiflora.
MedLine Citation:
PMID:  10785416     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leaf extracts of the Malaysian plant Aglaia laxiflora provided two cytotoxic compounds, a new rocaglaol rhamnoside (1), a known rocaglaol (2), new (but inactive) flavonol-cinnamaminopyrrolidine adducts (3-6), and their probable biosynthetic precursors (7 and trimethoxyflavonol). All structures were elucidated primarily by 2D NMR spectroscopy. The structure and stereochemistry of aglaxiflorin A (3) were confirmed by single-crystal X-ray crystallography.
Authors:
Y J Xu; X H Wu; B K Tan; Y H Lai; J J Vittal; Z Imiyabir; L Madani; K S Khozirah; S H Goh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of natural products     Volume:  63     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-06-23     Completed Date:  2000-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  473-6     Citation Subset:  IM    
Affiliation:
Department of Chemistry, National University of Singapore.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents, Phytogenic / isolation & purification*,  pharmacology
Crystallography, X-Ray
Drug Screening Assays, Antitumor
Heterocyclic Compounds, 3-Ring / isolation & purification*,  pharmacology
Humans
Leukemia P388 / drug therapy
Magnetic Resonance Spectroscopy
Malaysia
Mass Spectrometry
Mice
Molecular Conformation
Plants, Medicinal / chemistry*
Rats
Spectrometry, Mass, Fast Atom Bombardment
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Heterocyclic Compounds, 3-Ring

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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