| Flavonoids from Chinese Viscum coloratum produce cytoprotective effects against ischemic myocardial injuries: inhibitory effect of flavonoids on PAF-induced Ca2+ overload. | |
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MedLine Citation:
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PMID: 17724771 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Viscum coloratum has been used in the indigenous system of medicine for the treatment of various diseases such as myocardial ischemia and arrhythmia. Platelet-activating factor (PAF) is an important player in cardiovascular diseases. The aim of this study was to investigate the protective effects of Viscum coloratum flavonoids (VCF) against ischemic myocardial injuries in vivo and to further investigate its regulatory effect on PAF. Studies were performed in a rat model of myocardial infarction and in isolated myocytes. It was found that VCF relieved myocardial injuries during ischemia. PAF (10(-11) m) significantly increased the intracellular free Ca2+ concentration ([Ca2+]i) and VCF inhibited the changes induced by PAF in single cardiac myocytes. The results suggest that VCF can improve cardiac function and that VCF reduces ischemic myocardial injuries via blocking the signaling pathway of PAF. Therefore, PAF blockers may be candidate drugs for preventing cardiac injuries during ischemia/reperfusion, and subsequently improving cardiac function. |
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Authors:
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Wenfeng Chu; Guofen Qiao; Yunlong Bai; Zhenwei Pan; Guoyu Li; Xianmei Piao; Ling Wu; Yanjie Lu; Baofeng Yang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 22 ISSN: 0951-418X ISO Abbreviation: Phytother Res Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-03 Completed Date: 2008-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 134-7 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2007 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Pharmacology, Harbin Medical University, Harbin, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism Cardiovascular Agents / chemistry, pharmacology Dose-Response Relationship, Drug Drugs, Chinese Herbal / chemistry, pharmacology* Flavonoids / chemistry, pharmacology* Male Myocardial Reperfusion Injury / metabolism, prevention & control* Phytotherapy Platelet Activating Factor / pharmacology Random Allocation Rats Rats, Wistar Viscum / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 0/Drugs, Chinese Herbal; 0/Flavonoids; 0/Platelet Activating Factor; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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