Document Detail

Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials.
MedLine Citation:
PMID:  18614722     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The beneficial effects of flavonoid consumption on cardiovascular risk are supported by mechanistic and epidemiologic evidence. OBJECTIVE: We aimed to systematically review the effectiveness of different flavonoid subclasses and flavonoid-rich food sources on cardiovascular disease (CVD) and risk factors--ie, lipoproteins, blood pressure, and flow-mediated dilatation (FMD). DESIGN: Methods included a structured search strategy on MEDLINE, EMBASE, and Cochrane databases; formal inclusion or exclusion, data extraction, and validity assessment; and meta-analysis. RESULTS: One hundred thirty-three trials were included. No randomized controlled trial studied effects on CVD morbidity or mortality. Significant heterogeneity confirmed differential effects between flavonoid subclasses and foods. Chocolate increased FMD after acute (3.99%; 95% CI: 2.86, 5.12; 6 studies) and chronic (1.45%; 0.62, 2.28; 2 studies) intake and reduced systolic (-5.88 mm Hg; -9.55, -2.21; 5 studies) and diastolic (-3.30 mm Hg; -5.77, -0.83; 4 studies) blood pressure. Soy protein isolate (but not other soy products or components) significantly reduced diastolic blood pressure (-1.99 mm Hg; -2.86, -1.12; 9 studies) and LDL cholesterol (-0.19 mmol/L; -0.24, -0.14; 39 studies). Acute black tea consumption increased systolic (5.69 mm Hg; 1.52, 9.86; 4 studies) and diastolic (2.56 mm Hg; 1.03, 4.10; 4 studies) blood pressure. Green tea reduced LDL (-0.23 mmol/L; -0.34, -0.12; 4 studies). For many of the other flavonoids, there was insufficient evidence to draw conclusions about efficacy. CONCLUSIONS: To date, the effects of flavonoids from soy and cocoa have been the main focus of attention. Future studies should focus on other commonly consumed subclasses (eg, anthocyanins and flavanones), examine dose-response effects, and be of long enough duration to allow assessment of clinically relevant endpoints.
Lee Hooper; Paul A Kroon; Eric B Rimm; Jeffrey S Cohn; Ian Harvey; Kathryn A Le Cornu; Jonathan J Ryder; Wendy L Hall; Aedín Cassidy
Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  88     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-10     Completed Date:  2008-07-31     Revised Date:  2009-05-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  38-50     Citation Subset:  AIM; IM    
School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, United Kingdom.
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MeSH Terms
Blood Pressure / drug effects*
Cacao / chemistry*
Cardiovascular Diseases / blood,  epidemiology*
Endothelium, Vascular / drug effects*
Flavonoids / pharmacology*
Lipid Metabolism / drug effects*
Randomized Controlled Trials as Topic
Risk Factors
Soybean Proteins / pharmacology*
Tea / chemistry
Vitis / chemistry
Reg. No./Substance:
0/Flavonoids; 0/Soybean Proteins; 0/Tea
Comment In:
Am J Clin Nutr. 2008 Jul;88(1):12-3   [PMID:  18614717 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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