| Flavonoids and ent-labdane diterpenoids from Andrographis paniculata and their antiplatelet aggregatory and vasorelaxing effects. | |
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MedLine Citation:
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PMID: 18058376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two new flavones, designated as andropaniculosin A (1) and andropaniculoside A (2), and 30 known compounds were isolated as a result of detailed chemical examination on the whole plants of Andrographis paniculata. Their structures have been elucidated mainly by 1D and 2D NMR, and MS spectroscopic methods. Among them, four flavonoids showed potent inhibition of collagen, arachidonic acid, thrombin, and platelet activation factor induced platelet aggregation. Furthermore, a diterpenoid demonstrated moderate vasorelaxing effect in isolated rat thoracic aorta. |
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Authors:
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Tian-Shung Wu; Huei-Jen Chern; Amooru Gangaiah Damu; Ping-Chung Kuo; Chung-Ren Su; E-Jian Lee; Chi-Ming Teng |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of Asian natural products research Volume: 10 ISSN: 1028-6020 ISO Abbreviation: J Asian Nat Prod Res Publication Date: 2008 Jan-Feb |
Date Detail:
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Created Date: 2007-12-06 Completed Date: 2008-09-09 Revised Date: 2009-07-21 |
Medline Journal Info:
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Nlm Unique ID: 100888334 Medline TA: J Asian Nat Prod Res Country: England |
Other Details:
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Languages: eng Pagination: 17-24 Citation Subset: IM |
Affiliation:
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Department of Chemistry, National Cheng Kung University, Tainan, Taiwan. tswu@mail.ncku.edu.tw |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Andrographis
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chemistry* Animals Aorta / drug effects Diterpenes / chemistry, pharmacology* Flavonoids / chemistry, pharmacology* Molecular Structure Platelet Aggregation Inhibitors / chemistry, pharmacology* Rats Vasodilation / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Diterpenes; 0/Flavonoids; 0/Platelet Aggregation Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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