Document Detail


Flavonoids as superoxide scavengers and antioxidants.
MedLine Citation:
PMID:  2170243     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The superoxide anions scavenging activity and antioxidation of seven flavonoids--quercetin, rutin, morin, acacetin, hispidulin, hesperidin, and naringin--were studied. The superoxide anions were generated in a phenazin methosulphate-NADH system and were assayed by reduction of nitroblue tetrazolium. The scavenging activity ranked: rutin was the strongest, and quercetin and naringin the second, while morin and hispidulin were very weak. The concentration values yielding 50% inhibition of lipid peroxidation in mouse liver homogenate were in order of 10(-6) M for quercetin, rutin, and morin; and of 10(-5) M for acacetin and hispidulin, while naringin and hesperidin had no antioxidative action. In comparison with the antioxidative and scavenging activities of flavonoids, there are no correlations.
Authors:
Y T Chen; R L Zheng; Z J Jia; Y Ju
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Free radical biology & medicine     Volume:  9     ISSN:  0891-5849     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  1990  
Date Detail:
Created Date:  1990-11-15     Completed Date:  1990-11-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  19-21     Citation Subset:  IM    
Affiliation:
Department of Biology, Lanzhou University, Gansu Province, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / pharmacology*
Flavonoids / pharmacology*
Free Radicals
Lipid Peroxidation / drug effects
Liver / drug effects,  metabolism*
Mice
Superoxides / metabolism*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Flavonoids; 0/Free Radicals; 11062-77-4/Superoxides

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