Document Detail

Flavonoid quercetin protects against swimming stress-induced changes in oxidative biomarkers in the hypothalamus of rats.
MedLine Citation:
PMID:  19744476     Owner:  NLM     Status:  MEDLINE    
Quercetin is a bioflavonoid abundant in onions, apples, tea and red wine and one of the most studied flavonoids. Dietary quercetin intake is suggested to be health promoting, but this assumption is mainly based on mechanistic studies performed in vitro. The objective of this study was to investigate the effect of quercetin on stress-induced changes in oxidative biomarkers in the hypothalamus of rats. Adult male Sprague Dawley rats were subjected to forced swimming stress for 45 min daily for 14 days. Effect of quercetin at three different doses (10, 20 and 30 mg/kg body weight) on serum corticosterone and oxidative biomarkers (lipid hydroperoxides, antioxidant enzymes and total antioxidants) was estimated. Swimming stress significantly increased the serum corticosterone and lipid hydroperoxide levels. A significant decrease in total antioxidant levels and super oxide dismutase, glutathione peroxidase and catalase levels was seen in the hypothalamus after stress and treatment with quercetin significantly increased these oxidative parameters and there was a significant decrease in lipid hydroperoxide levels. These data demonstrate that forced swimming stress produced a severe oxidative damage in the hypothalamus and treatment with quercetin markedly attenuated these stress-induced changes. Antioxidant action of quercetin may be beneficial for the prevention and treatment of stress-induced oxidative damage in the brain.
Nagaraja Haleagrahara; Ammu Radhakrishnan; Nagarajah Lee; Ponnusamy Kumar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-08
Journal Detail:
Title:  European journal of pharmacology     Volume:  621     ISSN:  1879-0712     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-05     Completed Date:  2010-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  46-52     Citation Subset:  IM    
Division of Human Biology, Faculty of Medicine and Health, International Medical University, Kuala Lumpur, Malaysia.
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MeSH Terms
Antioxidants / metabolism
Biological Markers / metabolism
Catalase / metabolism
Corticosterone / blood
Glutathione Peroxidase / metabolism
Hypothalamus / drug effects*,  metabolism*
Lipid Peroxides / metabolism
Oxidative Stress / drug effects*
Quercetin / pharmacology*
Rats, Sprague-Dawley
Stress, Physiological*
Stress, Psychological*
Superoxide Dismutase / metabolism
Swimming / physiology*
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Lipid Peroxides; 117-39-5/Quercetin; 50-22-6/Corticosterone; EC; EC Peroxidase; EC Dismutase

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