Document Detail

Flavonoid nanocrystals produced by ARTcrystal(®)-technology.
MedLine Citation:
PMID:  25448550     Owner:  NLM     Status:  Publisher    
ARTcrystal(®)-technology is a novel technique for a more efficient production of nanocrystals. It consists of a high speed stirring (HSS) step as pre-milling and subsequent high pressure homogenization (HPH) at reduced pressure and cycle numbers. In this study, three antioxidants, rutin, hesperidin and apigenin, were processed by ARTcrystal(®)-technology, the results were compared to sizes obtained for the production of nanocrystals produced by classical HPH. By using the ARTcrystal(®)-process, all three substances could be transformed into nanosuspensions with mean sizes and PdIs of 431nm/0.27, 717nm/0.21 and 262nm/0.31, respectively. Depending on the properties of the raw material the ARTcrystal(®)-technology revealed similar or even better results than classical HPH. Further optimization of the setup of the HSS process might lead to an optimized process with higher efficacy than classical HPH.
Patrik Scholz; Cornelia M Keck
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-6
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  -     ISSN:  1873-3476     ISO Abbreviation:  Int J Pharm     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-3     Completed Date:  -     Revised Date:  2014-12-3    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier B.V. All rights reserved.
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